Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's
disease (AD), suggesting that activation of this innate immune receptor may be a useful …

Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years,
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …