Highlights•The main protease, known as M pro, is encoded by the viral genome and is
essential for viral replication.•The effective target for drug development has been the M …

With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …

ABSTRACT SARS-CoV-2 can enter cells after its spike protein is cleaved by either type II
transmembrane serine proteases (TTSPs), like TMPRSS2, or cathepsins. It is now widely …

The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main
protease, Spike protein, and RNA polymerase), compared with proteins of other human …

Significance: Although corona virus disease 2019 (COVID-19) has now gradually been
categorized as an endemic, the long-term effect of COVID-19 in causing multiorgan …

The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

Viral infections are amongst the most prevalent diseases that pose a significant threat to
human health. Targeting viral proteins or host factors represents two primary strategies for …

The severity of the SARS-CoV-2 pandemic and the recurring (re) emergence of viruses
prompted the development of new therapeutic approaches that target viral and host factors …

Background Camostat inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection in vitro. We studied the safety and efficacy of camostat in ACTIV-2/A5401, a …

Severe acute respiratory disease is associated with chronic secondary infections that
exacerbate symptoms and mortality. So far, many drugs have been introduced to treat this …