Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling

MS Hussain, O Afzal, G Kumar, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a
comprehensive understanding of its molecular foundations to establish effective treatment …

Crosstalk between long non-coding RNAs and p53 signaling pathway in colorectal cancer: A review study

MM Khanifar, Z Zafari, M Sheykhhasan - Pathology-Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and the third
leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key …

LncRNA LINC00969 promotes acquired gefitinib resistance by epigenetically suppressing of NLRP3 at transcriptional and posttranscriptional levels to inhibit …

J Dai, T Qu, D Yin, Y Cui, C Zhang, E Zhang… - Cell death & …, 2023 - nature.com
Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment prolongs
the survival of lung cancer patients harbouring activating EGFR mutations. However …

Targeting long non-coding RNAs in cancer therapy using CRISPR-Cas9 technology: a novel paradigm for precision oncology

RK Mahato, S Bhattacharya, N Khullar, IS Sidhu… - Journal of …, 2023 - Elsevier
Cancer is the second leading cause of death worldwide, despite recent advances in its
identification and management. To improve cancer patient diagnosis and care, it is …

Non-Coding RNAs as key regulators in lung cancer

I Gilyazova, G Gimalova, A Nizamova… - International journal of …, 2023 - mdpi.com
For several decades, most lung cancer investigations have focused on the search for
mutations in candidate genes; however, in the last decade, due to the fact that most of the …

Quadra-stable dynamics of p53 and PTEN in the DNA damage response

S Gupta, PK Panda, DA Silveira, R Ahuja… - Cells, 2023 - mdpi.com
Cell fate determination is a complex process that is frequently described as cells traveling on
rugged pathways, beginning with DNA damage response (DDR). Tumor protein p53 (p53) …

Involvement of lncRNA TUG1 in HIV-1 tat-induced astrocyte senescence

PP Pillai, M Kannan, S Sil, S Singh… - International journal of …, 2023 - mdpi.com
HIV-1 infection in the era of combined antiretroviral therapy has been associated with
premature aging. Among the various features of HIV-1 associated neurocognitive disorders …

lncRNA TUG1 as potential novel biomarker for prognosis of cardiovascular diseases

H Haybar, NS Sadati, D Purrahman… - …, 2023 - Taylor & Francis
Globally, cardiovascular diseases (CVDs) are among the leading causes of death. In light of
the high prevalence and mortality of CVDs, it is imperative to understand the molecules …

[HTML][HTML] Interplay of LncRNA TUG1 and TGF-β/P53 expression in colorectal cancer

BA Ibrahim, MA Gobran, AEM Metwalli… - Asian Pacific Journal …, 2023 - ncbi.nlm.nih.gov
Background: Colorectal cancer (CRC) is one of the most prevalent and deadly cancers
worldwide. It is still necessary to further define the mechanisms and explore the therapeutic …

Significant up-regulation of lncRNAs in neuromyelitis optica spectrum disorder

M Taheri, A Sadeghi, A Gharebaghi, M Ghiasian… - Scientific Reports, 2023 - nature.com
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-related demyelinating
defect. Long non-coding RNAs (lncRNAs) might influence the pathobiology and progression …