[HTML][HTML] A critical appraisal of clinical practice guidelines on pharmacological treatments for spinal cord injury

B Guan, Y Fan, R Zheng, R Fu, L Yao, W Wang, G Li… - The Spine Journal, 2023 - Elsevier
BACKGROUND CONTEXT Spinal cord injury brings devastating consequences and huge
economic burden. Different authoritative organizations have developed different guidelines …

In-hospital mortality rate in subaxial cervical spinal cord injury patients: a systematic review and meta-analysis

M Sadeghi-Naini, M Yousefifard, Z Ghodsi… - Acta …, 2023 - Springer
Purpose To determine existing trends concerning in-hospital mortality in patients with
traumatic subaxial cervical spinal cord injury (SCI) over the last four decades. Methods We …

Trends in the use of corticosteroids in the Management of Acute Spinal Cord Injury in north American clinical trials network sites

N Hejrati, B Aarabi, CJ Neal, B Ugiliweneza… - Journal of …, 2023 - liebertpub.com
Immunomodulatory therapeutics represent a potential neuroprotective strategy for the
management of acute spinal cord injury (SCI). One of the most intensely debated …

[PDF][PDF] The progress and controversies regarding steroid use in acute spinal cord injury.

WT Chen, YP Zhou, GS Zhang - European Review for Medical …, 2023 - europeanreview.org
Acute spinal cord injury (SCI) is a devastating disease that causes immense physical and
mental harm to the patient and the family, and society and requires a multidisciplinary …

Sex-related differences in epidemiology, treatment, and economic burden of traumatic spinal cord injury in China (2013–2018)

S Shang, C Wang, W Wang, J Wang, Y Lou, C Zhang… - Spine, 2023 - journals.lww.com
Study Design. Retrospective epidemiological study. Objective. To describe differences
based on biological sex in the epidemiology and treatment of the economic burden of …

Guidelines for management of pediatric acute hyperextension spinal cord injury

L Zeng, YL Wang, XT Shen, ZC Zhang… - Chinese Journal of …, 2023 - mednexus.org
Pediatric acute hyperextension spinal cord injury (SCI) named as PAHSCI by us, is a special
type of thoracolumbar SCI without radiographic abnormality and highly related to back-bend …

Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model

G Zheng, AK Harms, M Tail, H Zhang… - Frontiers in Molecular …, 2023 - frontiersin.org
Objective Disruption of the blood-spinal cord barrier (BSCB) with subsequent edema
formation and further neuroinflammation contributes to aggravation of spinal cord injury …

[HTML][HTML] Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice

AM Oprişoreanu, F Ryan, C Richmond… - Theranostics, 2023 - ncbi.nlm.nih.gov
Prolonged inflammation after spinal cord injury is detrimental to recovery. To find
pharmacological modulators of the inflammation response, we designed a rapid drug …

Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO‐1 pathway

LN Xuan, ZX Hu, ZF Jiang, C Zhang… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction As a devastating neurological disease, spinal cord injury (SCI) results in severe
tissue loss and neurological dysfunction. Pregnane X receptor (PXR) is a ligand‐activated …

Predicting the role of preoperative intramedullary lesion length and early decompressive surgery in ASIA impairment scale grade improvement following subaxial …

R Kamal, H Verma, S Narasimhaiah… - … Surgery Part A …, 2023 - thieme-connect.com
Background Traumatic cervical spinal cord injury (TCSCI) is a disabling condition with
uncertain neurologic recovery. Clinical and preclinical studies have suggested early surgical …