Antimicrobial peptide synergies for fighting infectious diseases

JT Mhlongo, AY Waddad, F Albericio… - Advanced …, 2023 - Wiley Online Library
Antimicrobial peptides (AMPs) are essential elements of thehost defense system.
Characterized by heterogenous structures and broad‐spectrumaction, they are promising …

Natural products acting against S. aureus through membrane and cell wall disruption

G Kumar, K Engle - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

[HTML][HTML] Analyzing mechanisms of action of antimicrobial peptides on bacterial membranes requires multiple complimentary assays and different bacterial strains

X Wang, RAM van Beekveld, Y Xu, A Parmar… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Antimicrobial peptides (AMPs) commonly target bacterial membranes and show broad-
spectrum activity against microorganisms. In this research we used three AMPs (nisin …

[HTML][HTML] Unlocking the microbial studies through computational approaches: how far have we reached?

R Kumar, G Yadav, M Kuddus, GM Ashraf… - … Science and Pollution …, 2023 - Springer
The metagenomics approach accelerated the study of genetic information from uncultured
microbes and complex microbial communities. In silico research also facilitated an …

2D-MoS 2-supported copper peroxide nanodots with enhanced nanozyme activity: application in antibacterial activity

A Kumari, J Sahoo, M De - Nanoscale, 2023 - pubs.rsc.org
Peroxidase (POD)-like nanozymes are an upcoming class of new-generation antibiotics that
are efficient for broad-spectrum antibacterial action. The POD-like activity employs the …

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

L Guo, J Wambui, C Wang, F Muchaamba… - Microbiology …, 2023 - Am Soc Microbiol
Nisin is a widely used lantibiotic owing to its potent antimicrobial activity and its food-grade
status. Its mode of action includes cell wall synthesis inhibition and pore formation, which …

Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections

EJA Douglas, SW Wulandari, SD Lovell… - Microbial …, 2023 - Wiley Online Library
Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and
currently represents one of the most significant threats to global health. Staphylococcus …

Pepsin: An excellent proteolytic enzyme for the production of bioactive peptides

TJ Ashaolu, CC Lee, JO Ashaolu, O Tarhan… - Food Reviews …, 2023 - Taylor & Francis
The production of bioactive peptides (BPs) usually involves the enzymatic hydrolysis stage
during which one or more proteases are used to break down the parental protein into shorter …

Challenges and advances in antimicrobial peptide development

KBS de Oliveira, ML Leite, VA Cunha, NB da Cunha… - Drug Discovery …, 2023 - Elsevier
Microbial resistance is a major concern for public health worldwide, mainly because of the
inappropriate use of antimicrobials. In this scenario, antimicrobial peptides (AMPs) have …

Antimicrobial peptide nanoparticle-based microneedle patches for the treatment of bacteria-infected wounds

B Wang, D Zhao, Y Li, X Zhou, Z Hui, X Lei… - ACS Applied Nano …, 2023 - ACS Publications
To avoid the production of drug resistance during the antibiotic treatment of wound infection,
the use of antimicrobial peptides (AMPs) has been strongly developed. However, its …