Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Tumor microenvironments (TMEs) influence cancer progression but are complex and often
differ between patients. Considering that microenvironment variations may reveal rules …

Background Head and neck squamous cell carcinoma (HNSCC) is the most common head
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …

Head and neck squamous cell carcinoma (HNSCC) undergoes stepwise progression from
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …

Background Patients with recurrent or metastatic head and neck squamous cell carcinoma
(R/M HNSCC) have a poor prognosis. The phase III KESTREL study evaluated the efficacy …

Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …

BACKGROUND Head and neck squamous cell carcinoma not associated with HPV (HPV-
unrelated HNSCC) is associated with a high rate of recurrence and poor survival …

Abstract Analysis of premalignant tissue has identified the typical order of somatic events
leading to invasive tumors in several cancer types. For other cancers, premalignant tissue is …