The implications of cannabinoid-induced metabolic dysregulation for cellular differentiation and growth

T Podinić, G Werstuck, S Raha - International Journal of Molecular …, 2023 - mdpi.com
The endocannabinoid system (ECS) governs and coordinates several physiological
processes through an integrated signaling network, which is responsible for inducing …

Inhibition of WNT signaling by conjugated microRNA nano-carriers: A new therapeutic approach for treating triple-negative breast cancer a perspective review

M Banerjee, VD Rajeswari - Critical Reviews in Oncology/Hematology, 2023 - Elsevier
Abstract Triple-Negative Breast Cancer is the most aggressive form and accounts the 15%−
25% of all breast cancer. Receptors are absent in triple-negative breast cancer, which …

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer

I Tundidor, M Seijo-Vila, S Blasco-Benito… - Nature …, 2023 - nature.com
Clinical management of breast cancer (BC) metastasis remains an unmet need as it
accounts for 90% of BC-associated mortality. Although the luminal subtype, which …

Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling Platform

DA Bunsick, J Matsukubo, MR Szewczuk - Cancers, 2023 - mdpi.com
Simple Summary The epigenome is dynamic and flexible and can influence its phenotype
by turning the genes on and off based on the environment to which it is exposed. Significant …

[HTML][HTML] FAAH inhibition ameliorates breast cancer in a murine model

M Tripathy, A Bui, J Henderson, J Sun, CR Woods… - Oncotarget, 2023 - ncbi.nlm.nih.gov
Breast cancer is the leading cancer among females worldwide. Disease outcome depends
on the hormonal status of the cancer and whether or not it is metastatic, but there is a need …

Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain

NG Hösch, BB Martins, QA Alcantara, MC Bufalo… - European Journal of …, 2023 - Elsevier
The aberrant activation of Wnt/β-catenin and atypical Wnt/Ryk signaling pathways in the
spinal cord is critical for the development and maintenance of neuropathic pain. Crotalphine …

The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas …

DZ Doyuran, Ö Eronat - The International Journal of …, 2023 - journals.sagepub.com
Introduction Papillary thyroid carcinoma is the most common malignancy of the endocrine
system. Most papillary thyroid carcinoma patients enjoy excellent outcomes. However, in …

Cytotoxic Potential of Rare Plant Salvia candidissima subsp. candidissima on Breast Cancer Cells

E Erturk, OE Onur, I Aydin, MZ Ozel, M Firat… - Brazilian Archives of …, 2023 - SciELO Brasil
Breast cancer is the leading cause of cancer-related deaths in women throughout the world.
Research on natural anti-cancer products from plants has gained traction. Salvia L. species …

Tetrahydrocannabinol derivative ameliorates 5-FU mediated DNA damage propensity coupled with Vimentin suppression leading to autophagy induction

A Goswami, K Mir, S Chakraborty, T Amin, A Kumar… - 2023 - researchsquare.com
Anastasis cascade including induction of Epithelial to Mesenchymal Transition (EMT), DNA
repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance …

The consequences of Cannabinoid receptor 2 expression in HER2+ breast cancer

N Roth - 2023 - qmro.qmul.ac.uk
Overexpression of the receptor tyrosine kinase HER2 (ERBB2) leads to an aggressive form
of breast cancer. In the past two decades many HER2-targeted therapies have been …