Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed
millions of lives. Unlike the early days of the pandemic, when management decisions were …

Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

Importance The longer-term effects of therapies for the treatment of critically ill patients with
COVID-19 are unknown. Objective To determine the effect of multiple interventions for …

Introduction Drug repositioning is a strategy to identify a new therapeutic indication for
molecules that have been approved for other conditions, aiming to speed up the traditional …

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor
clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin …

Background Bladder cancer is the most common malignancy of the urinary system.
However, patient prognosis and treatment outcomes in bladder cancer are difficult to predict …

Background Since 2005, the cardioprotective effects of glucagon-like peptide 1 receptor
agonists (GLP-1 RAs) have garnered attention. The cardioprotective effect could be an …

The development of effective antiviral compounds is essential for mitigating the effects of the
COVID-19 pandemic. Entry of SARS-CoV-2 virions into host cells is mediated by the …

The study aimed to evaluate severe COVID-19 treatment approaches. We conducted a meta-
analysis of randomized controlled trials (RTCs) with standard of care (SoC) as a control …

BACKGROUND The efficacy of simvastatin in critically ill patients with coronavirus disease
2019 (Covid-19) is unclear. METHODS In an ongoing international, multifactorial, adaptive …