[HTML][HTML] Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD

AA Calderon, C Dimond, DF Choy… - European …, 2023 - Eur Respiratory Soc
Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are
released upon airway epithelial injury from insults such as viruses and cigarette smoke, and …

Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s

K Saito, K Orimo, T Kubo, M Tamari, A Yamada… - Allergy, 2023 - Wiley Online Library
Introduction Epidemiological studies demonstrated that cleaning work and frequent use of
cleaning products are risk factors for asthma. Laundry detergents have been reported to …

Decoding the genetic and epigenetic basis of asthma

BS Stikker, RW Hendriks, R Stadhouders - Allergy, 2023 - Wiley Online Library
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

[HTML][HTML] Airway remodeling heterogeneity in asthma and its relationship to disease outcomes

A Hsieh, N Assadinia, TL Hackett - Frontiers in physiology, 2023 - frontiersin.org
Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Protease allergens as initiators–regulators of allergic inflammation

WT Soh, J Zhang, MD Hollenberg, H Vliagoftis… - Allergy, 2023 - Wiley Online Library
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …

[HTML][HTML] IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline

G Scott, S Asrat, J Allinne, WK Lim, K Nagashima… - Cytokine, 2023 - Elsevier
Abstract Rationale Type 2 (T2) asthma is characterized by airflow limitations and elevated
levels of blood and sputum eosinophils, fractional exhaled nitric oxide, IgE, and periostin …

TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis

Y Rochman, M Kotliar, N Ben-Baruch Morgenstern… - Science …, 2023 - science.org
The cytokine thymic stromal lymphopoietin (TSLP) mediates type 2 immune responses, and
treatments that interfere with TSLP activity are in clinical use for asthma. Here, we …

The understanding of asthma pathogenesis in the era of precision medicine

N Hizawa - Allergology International, 2023 - jstage.jst.go.jp
abstract Asthma is a syndrome with extremely diverse clinical phenotypes in which the
onset, severity, and response to treatment are defined by the complex interplay of many …

[HTML][HTML] Knowledge mapping and research trends of IL-33 from 2004 to 2022: a bibliometric analysis

J Jin, Y Wan, Q Shu, J Liu, D Lai - Frontiers in Immunology, 2023 - frontiersin.org
Background IL-33 has been studied widely but its comprehensive and systematic
bibliometric analysis is yet available. The present study is to summarize the research …