[HTML][HTML] Research advances in peptide‒drug conjugates

L Gong, H Zhao, Y Liu, H Wu, C Liu, S Chang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently
coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy …

Therapeutic supramolecular polymers: Designs and applications

H Wang, J Mills, B Sun, H Cui - Progress in Polymer Science, 2023 - Elsevier
The self-assembly of low-molecular-weight building motifs into supramolecular polymers
has unlocked a new realm of materials with distinct properties and tremendous potential for …

Application of molecular dynamics simulation in self-assembled cancer nanomedicine

X Xu, A Liu, S Liu, Y Ma, X Zhang, M Zhang… - Biomaterials …, 2023 - spj.science.org
Self-assembled nanomedicine holds great potential in cancer theragnostic. The structures
and dynamics of nanomedicine can be affected by a variety of non-covalent interactions, so …

Drug Self‐Delivery Systems: Molecule Design, Construction Strategy, and Biological Application

C Liu, C Liu, Y Bai, J Wang… - Advanced Healthcare …, 2023 - Wiley Online Library
Drug self‐delivery systems (DSDSs) offer new ways to create novel drug delivery systems
(DDSs). In typical DSDSs, therapeutic reagents are not considered passive cargos but active …

Stimulus‐Responsive Nano‐Prodrug Strategies for Cancer Therapy: A Focus on Camptothecin Delivery

B Chu, H Deng, T Niu, Y Qu, Z Qian - Small Methods, 2023 - Wiley Online Library
Camptothecin (CPT) is a highly cytotoxic molecule with excellent antitumor activity against
various cancers. However, its clinical application is severely limited by poor water solubility …

Reactive oxygen species‐responsive polymeric prodrug nanoparticles for selective and effective treatment of inflammatory diseases

Y Zhang, L Liu, T Wang, C Mao, P Shan… - Advanced …, 2023 - Wiley Online Library
It is challenging to manage inflammatory diseases using traditional anti‐inflammatory drugs
due to their limited efficacy and systemic side effects, which are a result of their lack of …

Core–shell type lipidic and polymeric nanocapsules: the transformative multifaceted delivery systems

A Mehandole, N Walke, S Mahajan, M Aalhate… - AAPS …, 2023 - Springer
Amongst the several nano-drug delivery systems, lipid or polymer-based core–shell
nanocapsules (NCs) have garnered much attention of researchers owing to its …

NIR-responsive carrier-free nanoparticles based on berberine hydrochloride and indocyanine green for synergistic antibacterial therapy and promoting infected …

Y Duan, P Xu, P Ge, L Chen, Y Chen… - Regenerative …, 2023 - academic.oup.com
Bacterial infections cause severe health conditions, resulting in a significant economic
burden for the public health system. Although natural phytochemicals are considered …

Self-Assembled Nanobiomaterials for Combination Immunotherapy

J Paul V, P Sharma, A Shanavas - ACS Applied Bio Materials, 2023 - ACS Publications
Nanotechnological interventions for cancer immunotherapy are a rapidly evolving paradigm
with immense potential. Self-assembled nanobiomaterials present safer alternatives to their …

Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy

G Yuan, Y Zhang, S Shao, Z Zhou, J Tang… - Journal of Controlled …, 2023 - Elsevier
Drug self-delivery systems (DSDSs) have been extensively exploited to enhance drug
loading capacity and avoid excipient-related toxicity issues. However, deficient tumor …