The positive relationship between increased levels of circulating triglycerides and
cardiovascular events has been observed for decades. Driven by genetic cohort studies …

The availability of pharmacological approaches able to effectively reduce circulating low-
density lipoprotein cholesterol (LDL-C) has led to a substantial reduction in the risk of …

The lipolytic processing of triglyceride-rich lipoproteins (TRLs) by lipoprotein lipase (LPL) is
crucial for the delivery of dietary lipids to the heart, skeletal muscle, and adipose tissue. The …

Abstract Aims Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and
is therefore a possible target for treating hypertriglyceridemia. Its relationship with …

APOA1 and APOB are the structural proteins of high-density lipoprotein and APOB-
containing lipoproteins, such as low-density lipoprotein and very low-density lipoprotein …

High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in
important functions such as reverse cholesterol transport and immunomodulatory activities …

Simple Summary Apolipoproteins (APOs) are crucial components in our blood that are
responsible for fat management. Recent scientific discoveries suggest a provocative link …

Introduction Defects in lipolysis can lead to hypertriglyceridemia, which can trigger acute
pancreatitis and is also associated with cardiovascular disease. Decreasing plasma …

GPIHBP1 is a protein found in the endothelial cells of capillaries that is anchored by
glycosylphosphatidylinositol and binds to high-density lipoproteins. GPIHBP1 attaches to …

Apolipoprotein (apo) C-II, whose two-dimensional structure is shown in the middle left, is the
product of the APOC2 gene, which is part of the APOE–C1–C4–C2 (APO) gene cluster on …