Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease

ME Hurley, E White, TMD Sheard, D Steele… - Open …, 2023 - royalsocietypublishing.org
Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the
fastest types of cytoplasmic second messenger signalling in excitable cells. In the heart …

Disrupted T‐tubular network accounts for asynchronous calcium release in MTM1‐deficient skeletal muscle

P Szentesi, B Dienes, C Kutchukian… - The Journal of …, 2023 - Wiley Online Library
In mammalian skeletal muscle, the propagation of surface membrane depolarization into the
interior of the muscle fibre along the transverse (T) tubular network is essential for the …

Evaluation of Human-Induced Pluripotent Stem Cells Derived from a Patient with Schwartz–Jampel Syndrome Revealed Distinct Hyperexcitability in the Skeletal …

Y Yamashita, S Nakada, K Nakamura, H Sakurai… - Biomedicines, 2023 - mdpi.com
Schwartz–Jampel syndrome (SJS) is an autosomal recessive disorder caused by loss-of-
function mutations in heparan sulfate proteoglycan 2 (HSPG2), which encodes the core …

Excitation–contraction coupling in skeletal muscle: fast Ca2+ signaling for muscle activation

MF Schneider… - Calcium Signals: From …, 2023 - iopscience.iop.org
This chapter summarizes the early and intermediate steps in the skeletal muscle excitation-
contraction coupling process. Emphasis is placed on the events needed to generate an …

Prediction of fast subcellular Ca2+ signals based on subcellular structures in label-free second harmonic generation microscopy measurements

T Georgiev - bioRxiv, 2023 - biorxiv.org
Ca2+ sparks were predicted based on the label-free second harmonic generation (SHG)
signal of myosin filaments with pix2pix, a conditional adversarial network. Predicted Ca2+ …

An Investigation into the Role of Collagen VI in the Myocardium

BL Anzellotti - 2023 - researchspace.auckland.ac.nz
The role of collagen VI in the myocardium is still largely unknown. Mostly being linked to
muscular dystrophies such as Bethlem muscular dystrophy and Ullrich congenital muscular …

[PDF][PDF] Aus dem Institut für Herz-und Kreislaufphysiologie der Heinrich-Heine-Universität Düsseldorf Direktor: Prof. Dr. rer. nat. Axel Gödecke

AJ Kollenbroich - docserv.uni-duesseldorf.de
In dB+ Tieren waren 12 Tage nach IR sowohl die passive als auch die aktive Kraft der
untersuchten Muskeln signifikant gesteigert. Bei dBdB war im Musculus psoas (M. psoas) …