Amyotrophic lateral sclerosis (ALS) is a neuronal degenerative condition identified via a
build-up of mutant aberrantly folded proteins. The native folding of polypeptides is mediated …

There is substantial experimental and clinical interest in providing effective ways to both
prevent and slow the onset of hearing loss. Auditory hair cells, which occur along the basilar …

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease mostly resulting
from a complex interplay between genetic, environmental and lifestyle factors. Common …

Abstract Heat shock factor 1 (HSF1) is a master stress‐responsive transcriptional factor,
protecting cells from death. However, its gene regulation in vivo in the brain in response to …

Neurons are challenged to maintain proteostasis in neuronal projections, particularly with
the physiological stress at synapses to support intercellular communication underlying …

Proteostasis is maintained through regulated protein synthesis and degradation and
chaperone-assisted protein folding. However, this is challenging in neuronal projections …

Understanding the mechanisms that drive TDP-43 pathology is integral to combating
neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal …

Type 2 Diabetes and Alzheimer's Disease share many common features, including one
examined in this thesis: the build-up of proteins into toxic plaque in vital organs. The thesis …

The brain is uniquely vulnerable to cellular stress, making it crucial to understand the
mechanisms that regulate stress response. N6-methyladenosine (m 6 A), the most prevalent …