Histone renegades: Unusual H2A histone variants in plants and animals
A Osakabe, A Molaro - Seminars in Cell & Developmental Biology, 2023 - Elsevier
H2A variants are histones that carry out specialized nucleosome function during the
eukaryote genome packaging. Most genes encoding H2A histone variants arose in the …
eukaryote genome packaging. Most genes encoding H2A histone variants arose in the …
Machines on genes through the computational microscope
Macromolecular machines acting on genes are at the core of life's fundamental processes,
including DNA replication and repair, gene transcription and regulation, chromatin …
including DNA replication and repair, gene transcription and regulation, chromatin …
Histone variant H2A. Z modulates nucleosome dynamics to promote DNA accessibility
Nucleosomes containing the histone variant H2A. Z are important for gene transcription
initiation and termination, chromosome segregation and DNA double-strand break repair …
initiation and termination, chromosome segregation and DNA double-strand break repair …
Coarse-Grained Models to Study Protein–DNA Interactions and Liquid–Liquid Phase Separation
Recent advances in coarse-grained (CG) computational models for DNA have enabled
molecular-level insights into the behavior of DNA in complex multiscale systems. However …
molecular-level insights into the behavior of DNA in complex multiscale systems. However …
H2a ubiquitination alters H3-tail dynamics on linker-DNA to enhance H3K27 methylation
H Ohtomo, S Ito, NJ McKenzie, M Uckelmann… - Journal of Molecular …, 2023 - Elsevier
Abstract Polycomb repressive complex 1 (PRC1) and PRC2 are responsible for epigenetic
gene regulation. PRC1 ubiquitinates histone H2A (H2Aub), which subsequently promotes …
gene regulation. PRC1 ubiquitinates histone H2A (H2Aub), which subsequently promotes …
C–B–A test of DNA force fields
IA Strelnikov, NA Kovaleva, AP Klinov, EA Zubova - ACS omega, 2023 - ACS Publications
The DNA duplex may be locally strongly bent in complexes with proteins, for example, with
polymerases or in a nucleosome. At such bends, the DNA helix is locally in the …
polymerases or in a nucleosome. At such bends, the DNA helix is locally in the …
Structure and Dynamics of Compact Dinucleosomes: Analysis by Electron Microscopy and spFRET
ME Stefanova, OI Volokh, OV Chertkov… - International Journal of …, 2023 - mdpi.com
Formation of compact dinucleosomes (CODIs) occurs after collision between adjacent
nucleosomes at active regulatory DNA regions. Although CODIs are likely dynamic …
nucleosomes at active regulatory DNA regions. Although CODIs are likely dynamic …
Arginine anchor points govern H3 tail dynamics
CE Jennings, CJ Zoss, EA Morrison - Frontiers in Molecular …, 2023 - frontiersin.org
Chromatin is dynamically reorganized spatially and temporally, and the post-translational
modification of histones is a key component of this regulation. The basic subunit of …
modification of histones is a key component of this regulation. The basic subunit of …
NucleosomeDB-a database of 3D nucleosome structures and their complexes with comparative analysis toolkit
Nucleosomes are basic building blocks of chromatin, comprising DNA wrapped around an
octamer of eight histone proteins. They play key roles in DNA compaction, epigenetic mark …
octamer of eight histone proteins. They play key roles in DNA compaction, epigenetic mark …
[HTML][HTML] A coarse-grained DNA model to study protein-DNA interactions and liquid-liquid phase separation
Recent advances in coarse-grained (CG) computational models for DNA have enabled
molecular-level insights into the behavior of DNA in complex multiscale systems. However …
molecular-level insights into the behavior of DNA in complex multiscale systems. However …