The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …

Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

Malonylation is a recently identified post-translational modification with malonyl-coenzyme A
as the donor. It conserved both in prokaryotes and eukaryotes. Recent advances in the …

Significance: Type 2 diabetes mellitus, which is related to oxidative stress and mitochondrial
dysfunction, is one of the most prevalent diseases in the world. In the past decade …

While impairments in peripheral tissue insulin signalling have a well-characterized role in
the development of insulin resistance and type 2 diabetes (T2D), the specific mechanisms …

Impaired mitochondrial dynamics causes aging-related or metabolic diseases. Yet, the
molecular mechanism responsible for the impairment of mitochondrial dynamics is still not …

Mitochondrial aldehyde dehydrogenase (ALDH2) offers proven cardiovascular benefit
although its impact in diabetes remains elusive. This study examined the effect of ALDH2 …

Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive
loss of dopaminergic neurons in the nigrostriatal pathway. Although the exact mechanisms …

The pathophysiological mechanisms intersecting metabolic and neurodegenerative
disorders include insulin resistance, which has a strong involvement of environmental …