[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

VS Peche, TA Pietka, M Jacome-Sosa… - Nature …, 2023 - nature.com
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

Palmitic acid‐induced ferroptosis via CD36 activates ER stress to break calcium‐iron balance in colon cancer cells

H Kuang, X Sun, Y Liu, M Tang, Y Wei, Y Shi… - The FEBS …, 2023 - Wiley Online Library
Ferroptosis, featuring an iron‐dependent peroxidation of lipids, is a novel form of
programmed cell death that may hold great potential in cancer therapy. Our study found that …

Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets

SK Tan, HY Hougen, JR Merchan, ML Gonzalgo… - Nature Reviews …, 2023 - nature.com
Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …

A systematic review of the biological mediators of fat taste and smell

RB Jaime-Lara, BE Brooks, C Vizioli… - Physiological …, 2023 - journals.physiology.org
Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly
palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is …

Transporter-mediated drug delivery

G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

C Bertoncini‐Silva, JM Zingg, PG Fassini… - BioFactors, 2023 - Wiley Online Library
Obesity is the result of the long‐term energy imbalance between the excess calories
consumed and the few calories expended. Reducing the intake of energy dense foods (fats …

Liver-derived metabolites as signaling molecules in fatty liver disease

U Keles, JR Ow, KB Kuentzel, LN Zhao… - Cellular and Molecular …, 2023 - Springer
Excessive fat accumulation in the liver has become a major health threat worldwide.
Unresolved fat deposition in the liver can go undetected until it develops into fatty liver …

Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses

Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan… - Cell Metabolism, 2023 - cell.com
Autoreactive B cell responses are essential for the development of systemic lupus
erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to construct lymphoid …