[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …
considered two of the most important causes of death. Experimental and clinical evidence …
Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
Palmitic acid‐induced ferroptosis via CD36 activates ER stress to break calcium‐iron balance in colon cancer cells
H Kuang, X Sun, Y Liu, M Tang, Y Wei, Y Shi… - The FEBS …, 2023 - Wiley Online Library
Ferroptosis, featuring an iron‐dependent peroxidation of lipids, is a novel form of
programmed cell death that may hold great potential in cancer therapy. Our study found that …
programmed cell death that may hold great potential in cancer therapy. Our study found that …
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …
A systematic review of the biological mediators of fat taste and smell
RB Jaime-Lara, BE Brooks, C Vizioli… - Physiological …, 2023 - journals.physiology.org
Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly
palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is …
palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is …
Transporter-mediated drug delivery
G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation
Obesity is the result of the long‐term energy imbalance between the excess calories
consumed and the few calories expended. Reducing the intake of energy dense foods (fats …
consumed and the few calories expended. Reducing the intake of energy dense foods (fats …
Liver-derived metabolites as signaling molecules in fatty liver disease
Excessive fat accumulation in the liver has become a major health threat worldwide.
Unresolved fat deposition in the liver can go undetected until it develops into fatty liver …
Unresolved fat deposition in the liver can go undetected until it develops into fatty liver …
Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses
Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan… - Cell Metabolism, 2023 - cell.com
Autoreactive B cell responses are essential for the development of systemic lupus
erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to construct lymphoid …
erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to construct lymphoid …