Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies

NC Brembilla, WH Boehncke - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a common chronic inflammatory skin disease, associated with substantial
comorbidity. TH17 lymphocytes, differentiating under the influence of dendritic cell-derived …

Inflammation and psoriasis: a comprehensive review

AM Man, MS Orăsan, OA Hoteiuc… - International Journal of …, 2023 - mdpi.com
Psoriasis is an immune-mediated disease with a strong genetic component that brings many
challenges to sick individuals, such as chronic illness, and which has multiple associated …

Efficacy and safety of IL-23 inhibitors in the treatment of psoriatic arthritis: a meta-analysis based on randomized controlled trials

X Huang, H Shentu, Y He, H Lai, C Xu, M Chen… - Immunologic …, 2023 - Springer
In recent years, the use of interleukin (IL) 23 inhibitors in the treatment of psoriatic arthritis
(PsA) has been the subject of much research. By specifically binding to the p19 subunit of IL …

Psoriasis and hidradenitis suppurativa: a large-scale population-based study

K Kridin, M Shani, Y Schonmann, S Fisher… - Journal of the American …, 2023 - Elsevier
Background The coexistence of psoriasis and hidradenitis suppurativa (HS) has been
described, but the association between these conditions is yet to be firmly established …

The experimental animal models in psoriasis research: a comprehensive review

S Parab, G Doshi - International Immunopharmacology, 2023 - Elsevier
Psoriasis is an autoimmune, chronic, inflammatory skin condition mediated by T cells. It
differs from other inflammatory conditions by causing significant alterations in epidermal cell …

Drug Utilization and Measurement of Medication Adherence: A Real World Study of Psoriasis in Italy

S Mucherino, C Rafaniello, M Serino, A Zinzi, U Trama… - Pharmaceutics, 2023 - mdpi.com
Exceptional advances have been made with systemic treatment for psoriasis (PSO).
However, that disease still represents a heavy burden in terms of impact on healthcare …

[HTML][HTML] Deucravacitinib for the treatment of psoriatic arthritis: the evidence so far

A Martins, AM Lé, T Torres - Drugs in Context, 2023 - ncbi.nlm.nih.gov
Psoriatic arthritis (PsA) is a heterogeneous disease that may develop in up to 30% of
patients with psoriasis. PsA mainly involves peripheral joints; however, axial skeleton and …

Benzoylaconitine alleviates progression of psoriasis via suppressing STAT3 phosphorylation in keratinocytes

Y Li, D Guo, Q Wang, A Li, S Yin, S Li, Y Li, B Wang… - Molecules, 2023 - mdpi.com
Psoriasis is a chronic and multifactorial skin disease which is caused by inflammatory
infiltrates, keratinocyte hyperproliferation, and accumulation of immune cells. As part of the …

SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes

C Wang, D He, C Shi - Allergologia et Immunopathologia, 2023 - all-imm.com
Psoriasis is a chronic multisystemic inflammatory disease with inflammatory cell infiltration,
hyperproliferation of keratinocytes in skin lesions, and epidermal barrier dysfunction. Normal …

Isostearic acid is an active component of imiquimod formulations used to induce psoriaform disease models

S Straß, J Geiger, M Martorelli, S Geiger, N Cloos… - …, 2023 - Springer
Topical imiquimod based creams are indicated as immune stimulants for papillomas and
various skin neoplasms. Imiquimod is considered a TLR7 ligand. These creams are also …