Astrocytes: Lessons Learned from the Cuprizone Model

M Kipp - International Journal of Molecular Sciences, 2023 - mdpi.com
A diverse array of neurological and psychiatric disorders, including multiple sclerosis,
Alzheimer's disease, and schizophrenia, exhibit distinct myelin abnormalities at both the …

[HTML][HTML] Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple …

KM Al-Otaibi, BS Alghamdi, MA Al-Ghamdi… - Frontiers in Behavioral …, 2023 - frontiersin.org
Stimulation of remyelination is critical for the treatment of multiple sclerosis (MS) to alleviate
symptoms and protect the myelin sheath from further damage. The current study aimed to …

Balance beam crossing times are slower after noise exposure in rats

D Bartikofsky, MJ Hertz, DS Bauer… - Frontiers in Integrative …, 2023 - frontiersin.org
Introduction The vestibular system integrates signals related to vision, head position, gravity,
motion, and body position to provide stability during motion through the environment …

Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of Multiple Sclerosis

S Barriola, LM Delgado-García, P Cartas-Cejudo… - Neuroscience, 2023 - Elsevier
Multiple sclerosis (MS) is a complex autoimmune and neurodegenerative disorder that
affects the central nervous system (CNS). It is characterized by a heterogeneous disease …

Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions

SG Gakare, JM Bhatt, KKS Narasimhan, SM Dravid - PloS one, 2023 - journals.plos.org
In this study, we investigated the role of glutamate delta 1 receptor (GluD1) in
oligodendrocyte progenitor cell (OPC)-mediated myelination during basal (development) …

Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination

S Yamamoto, K Iwasa, A Yamagishi, C Haruta… - Journal of …, 2023 - Elsevier
The cuprizone (CPZ)-induced demyelination model, an animal model of Multiple sclerosis
(MS), is characterized by demyelination and motor dysfunction due to microglial-mediated …

Neuromodulation of neurological disorders in a demyelination model: effect of a potassium channel inhibitor from Androctonus scorpion venom

H Moussaoui, A Ladjel-Mendil, F Laraba-Djebari - Toxin Reviews, 2023 - Taylor & Francis
Scorpion's toxins have attracted attention as a treatment for diverse neurological diseases
related to myelin loss. This study aimed to investigate the effect of kaliotoxin2 (KTX2), a …

[PDF][PDF] Kholoud M. Al-Otaibi1, 2*, Badrah S. Alghamdi3, 4*, Maryam A. Al-Ghamdi1, 5, 6, Rasha A. Mansouri1

GM Ashraf, UM Omar - 2023 - researchgate.net
Multiple sclerosis (MS) is a chronic, demyelinating, progressive disease of the central
nervous system (CNS) characterized by inflammation, neurodegeneration, and axonal …

Studying The Molecular and Behavioral Mechanisms of Novel Therapeutics Combinations in Multiple Sclerosis Disease

KM Alotaibi - 2023 - platform.almanhal.com
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
(CNS) that destroys the myelin sheath, accompanied by a wide range of clinical …