Supramolecular Recognition of Cytidine Phosphate in Nucleotides and RNA Sequences
BS Morozov, AS Oshchepkov, I Klemt, AM Agafontsev… - JACS Au, 2023 - ACS Publications
Supramolecular recognition of nucleotides would enable manipulating crucial biochemical
pathways like transcription and translation directly and with high precision. Therefore, it …
pathways like transcription and translation directly and with high precision. Therefore, it …
Watson–Crick Base Pairs with Protecting Groups: The 2-Amino Groups of Purine-and 7-Deazapurine-2, 6-Diamine as Target Sites for DNA Functionalization by …
D Kondhare, X Heddinga, P Leonard… - Bioconjugate …, 2023 - ACS Publications
The recognition of Watson–Crick base pairs carrying nucleobase protecting groups is
reported as a new approach for DNA functionalization. The 2-amino groups of purine-and 7 …
reported as a new approach for DNA functionalization. The 2-amino groups of purine-and 7 …
Ligands for Abasic Site-containing DNA and their Use as Fluorescent Probes
J Schlosser, H Ihmels - Current Organic Synthesis, 2023 - ingentaconnect.com
Apurinic and apyrimidinic sites, also referred to as abasic or AP sites, are residues of duplex
DNA in which one DNA base is removed from a Watson-Crick base pair. They are formed …
DNA in which one DNA base is removed from a Watson-Crick base pair. They are formed …
Photoinduced Reactions of Styrylpyridine Derivatives for the In Situ Formation of Selective Ligands for Apyrimidinic DNA
J Schlosser, N Stötzel, Y Fedorov, H Ihmels - ChemPhotoChem, 2023 - Wiley Online Library
The photocyclization reaction of sterically demanding styrylpyridine derivatives was
investigated and shown to depend on the type of substituent. With this method, a 2, 2 …
investigated and shown to depend on the type of substituent. With this method, a 2, 2 …
Structural polymorphism driven by a register shift in a CGAG-rich region found in the promoter of the neurodevelopmental regulator AUTS2 gene
A Novotný, J Plavec, V Kocman - Nucleic Acids Research, 2023 - academic.oup.com
The AUTS2 gene has been shown to influence brain development by controlling the number
of neurons, promoting the growth of axons and dendrites and regulating neuronal migration …
of neurons, promoting the growth of axons and dendrites and regulating neuronal migration …
Enzyme-Free Colorimetric Method for Fast Detection of PIK3CA Gene Mutation by Praseodymia Nanorods
L Jiang, M Wang, Y Li, S Zhang, X Zhu… - Analytical …, 2023 - ACS Publications
The frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene
is associated with multiple tumors and endocytosis of viruses. Identification of muted …
is associated with multiple tumors and endocytosis of viruses. Identification of muted …
Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity
Y Sato, Y Takaku, T Nakano, K Akamatsu… - Chemical …, 2023 - pubs.rsc.org
Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence
sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A …
sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A …
Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2-N-carbamoyl-or (2-pyridyl) guanine
T Kanagawa, A Koyoma, Y Masaki… - Organic & Biomolecular …, 2023 - pubs.rsc.org
Antisense oligonucleotides (ASOs) are therapeutic modalities that are successfully used as
pharmaceuticals. However, there remains a concern that treatment with ASOs may cleave …
pharmaceuticals. However, there remains a concern that treatment with ASOs may cleave …
Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane
J Schlosser, JFM Hebborn, DV Berdnikova, H Ihmels - Chemistry, 2023 - mdpi.com
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host
system whose association with representative nucleotides was examined with photometric …
system whose association with representative nucleotides was examined with photometric …
Unique opportunities of metal scaffolds in drug design
M Liu, J Jiang, Z Xie, Y Yang, T Zou - Privileged Scaffolds in Drug …, 2023 - Elsevier
Metal complexes constitute a huge number of bioactive molecules that are widely studied
and clinically applied owing to their divergent functions and extensive biological properties …
and clinically applied owing to their divergent functions and extensive biological properties …