[HTML][HTML] Updates on malaria epidemiology and prevention strategies

M González-Sanz, P Berzosa, FF Norman - Current Infectious Disease …, 2023 - Springer
Abstract Purpose of Review The objective of this review was to provide an update on recent
malaria epidemiology, both globally and in non-endemic areas, to identify the current …

[HTML][HTML] The dual role of the innate immune system in the effectiveness of mRNA therapeutics

A Muslimov, V Tereshchenko, D Shevyrev… - International journal of …, 2023 - mdpi.com
Advances in molecular biology have revolutionized the use of messenger RNA (mRNA) as a
therapeutic. The concept of nucleic acid therapy with mRNA originated in 1990 when Wolff …

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria

DO Odera, J Tuju, K Mwai, IN Nkumama… - Science Translational …, 2023 - science.org
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …

[HTML][HTML] Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies

S Yanik, V Venkatesh, ML Parker… - Nature …, 2023 - nature.com
Invasion of human erythrocytes by Plasmodium falciparum (Pf) merozoites relies on the
interaction between two parasite proteins: apical membrane antigen 1 (AMA1) and rhoptry …

[PDF][PDF] WHO Guidelines for malaria, 14 March 2023

World Health Organization - 2023 - apps.who.int
This document is a PDF generated from the WHO Guidelines for malaria hosted on the
MAGICapp online platform: https://app. magicapp. org/#/guideline/6860. Each time the …

[HTML][HTML] Evaluation of a new fusion antigen, cd loop and HAP2-GCS1 domain (cd-HAP) of Plasmodium falciparum Generative Cell Specific 1 antigen formulated with …

Z Pourhashem, L Nourani, JJ Sani, H Yousefi… - Malaria Journal, 2023 - Springer
Background Malaria is a major global health challenge, and for the elimination and
eradication of this disease, transmission-blocking vaccines (TBVs) are a priority …

[HTML][HTML] Design, synthesis, and in silico studies of benzimidazoles of thymol as potent antiplasmodial and antimicrobial agents

RT Bhoi, CN Bhoi, SR Nikume, RS Bendre - Results in Chemistry, 2023 - Elsevier
This study presents an efficient one pot two steps synthesis of a new series of naturally
occurring phenolic monoterpenoid based (thymol) benzimidazole derivatives (3a-i) by green …

[HTML][HTML] Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies

P Srinivasan, S Yanik, V Venkatesh, M Parker… - Research …, 2023 - ncbi.nlm.nih.gov
Invasion of human red blood cells (RBCs) by Plasmodium falciparum (Pf) merozoites relies
on the interaction between two parasite proteins, apical membrane antigen 1 (AMA1) and …

Malaria Vaccines

MB Laurens, CV Plowe - Infectious Diseases, 2023 - books.google.com
crude early experiments in animals and humans using weakened whole parasites, but the
results of more sophisticated modern approaches using molecular techniques have ranged …

[PDF][PDF] VACCINE DEVELOPMENT USING PLATFORM TECHNOLOGIES

A Banerjee - Pharma Times, 2023 - researchgate.net
Traditional vaccines that employ whole-cell antigens to raise an immune response have
been irrefutably successful in the control or localized eradication of diseases such as …