Transgenerational epigenetic inheritance of traumatic experience in mammals
J Švorcová - Genes, 2023 - mdpi.com
In recent years, we have seen an increasing amount of evidence pointing to the existence of
a non-genetic heredity of the effects of events such as separation from parents, threat to life …
a non-genetic heredity of the effects of events such as separation from parents, threat to life …
[HTML][HTML] Spectacular role of epididymis and bio-active cargo of nano-scale exosome in sperm maturation: a review
W Ali, K Deng, Y Bian, Z Liu, H Zou - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The epididymis is responsible for post-testicular sperm maturation as it provides a favorable
environment for spermatozoa to gain the ability for movement and fertilization. The recent …
environment for spermatozoa to gain the ability for movement and fertilization. The recent …
Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring
N Alata Jimenez, M Castellano, EM Santillan… - Nature …, 2023 - nature.com
Folate is an essential vitamin for vertebrate embryo development. Methotrexate (MTX) is a
folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ …
folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ …
Preconception origins of asthma, allergies and lung function: the influence of previous generations on the respiratory health of our children
C Svanes, JW Holloway… - Journal of Internal …, 2023 - Wiley Online Library
Emerging research suggests that exposures occurring years before conception are
important determinants of the health of future offspring and subsequent generations …
important determinants of the health of future offspring and subsequent generations …
Sperm RNA payload: implications for intergenerational epigenetic inheritance
S Liu, U Sharma - International journal of molecular sciences, 2023 - mdpi.com
There is mounting evidence that ancestral life experiences and environment can influence
phenotypes in descendants. The parental environment regulates offspring phenotypes …
phenotypes in descendants. The parental environment regulates offspring phenotypes …
High-fat diet induced obesity alters Dnmt1 and Dnmt3a levels and global DNA methylation in mouse ovary and testis
G Sukur, F Uysal, O Cinar - Histochemistry and Cell Biology, 2023 - Springer
Obesity impairs reproductive capacity, and the link between imprinting disorders and obesity
has been discussed in many studies. Recent studies indicate that a high-fat diet may cause …
has been discussed in many studies. Recent studies indicate that a high-fat diet may cause …
The molecular basis of male infertility in obesity: A literature review
The rising incidence of obesity has coincided with rising levels of poor reproductive
outcomes. The molecular basis for the association of infertility in obese males is now being …
outcomes. The molecular basis for the association of infertility in obese males is now being …
Unaltered hepatic wound healing response in male rats with ancestral liver injury
J Beil, J Perner, L Pfaller, MA Gérard, A Piaia… - Nature …, 2023 - nature.com
The possibility that ancestral environmental exposure could result in adaptive inherited
effects in mammals has been long debated. Numerous rodent models of transgenerational …
effects in mammals has been long debated. Numerous rodent models of transgenerational …
Male obesity: Associated effects on fertility and the outcomes of offspring
G Venigalla, V Ila, J Dornbush, A Bernstein, J Loloi… - …, 2023 - Wiley Online Library
Obesity rates are increasing globally, making it imperative to comprehend the effects of
parental obesity on human reproduction. This review aims to highlight the impact of male …
parental obesity on human reproduction. This review aims to highlight the impact of male …
Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice
S Wei, S Luo, H Zhang, Y Li, J Zhao - Genes & Nutrition, 2023 - Springer
Paternal high-fat diet (HFD) can alter the epigenetics of sperm DNA, resulting in the
transmission of obesity-related traits to the offspring. Previous studies have mainly focused …
transmission of obesity-related traits to the offspring. Previous studies have mainly focused …