Cell division is the basis for the propagation of life and requires accurate duplication of all
genetic information. DNA damage created during replication (replication stress) is a major …

Primary microcephalies (PMs) are defects in brain growth that are detectable at or before
birth and are responsible for neurodevelopmental disorders. Most are caused by biallelic or …

TRAIP, as a 53 kDa E3 ubiquitin protein ligase, is involved in various cellular processes and
closely related to the occurrence and development of tumors. At present, few studies on the …

Increasing evidence highlights a robust correlation between the gut microbiota and bone
diseases; however, the existence of a causal relationship between them remains unclear. In …

Background Lung adenocarcinoma (LUAD) is one of the major types of lung cancer with
high morbidity and mortality. The TRAF-interacting protein (TRAIP) is a ring-type E3 ubiquitin …

Electronic cigarettes (e-cigarettes) are a prevalent alternative to conventional nicotine
cigarettes among smokers and people who have never smoked. Increased concentrations of …

Seckel syndrome is an ultrarare autosomal recessive genetically heterogenous condition
characterized by intrauterine and postnatal growth restriction, proportionate severe short …

TRAIP is a key factor involved in the DNA damage response (DDR), homologous
recombination (HR) and DNA interstrand crosslink (ICL) repair. However, the exact functions …

Loading PCNA onto chromatin is a pivotal step in DNA replication, cell cycle progression,
and genome integrity. Conversely, unloading PCNA from chromatin is also a crucial step for …

DONSON is a novel replisome and replication fork stabilisation factor that is essential for
efficient DNA replication and is particularly important during times of increased replicative …