The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

We report studies pertaining to two isomeric hexahydrocannabinols (HHCs),(9R)-HHC and
(9S)-HHC, which are derivatives of the psychoactive cannabinoids Δ9-and Δ8-THC. HHCs …

Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

In recent years, biomedical research efforts aimed to unravel the mechanisms involved in
motor neuron death that occurs in amyotrophic lateral sclerosis (ALS). While the main …

The endocannabinoid system (ECS) is a widespread cell signaling network that maintains
homeostasis in response to endogenous and exogenous stressors. This has made the ECS …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

The medical use of cannabis has a very long history. Although many substances called
cannabinoids are present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC), cannabidiol …

Chronic pain, one of the most common reasons adults seek medical care, has been linked to
restrictions in mobility and daily activities, dependence on opioids, anxiety, depression …

Cannabis has been used recreationally and medically for centuries, yet research into
understanding the mechanisms of its therapeutic effects has only recently garnered more …