Small nucleolar RNAs (snoRNAs) play critical roles in various biological processes. The
aberrant expression or depletion of snoRNAs is related to various diseases. In previous …

Abstract Purpose of Review This paper reviews how sleep is impacted in patients with
Prader-Willi syndrome (PWS), focusing on sleep-related breathing disturbances and …

Orphan diseases are rare diseases that affect less than 200000 individuals within the United
States. Most orphan diseases are of neurologic and genetic origin. With the current …

The hypothalamus regulates fundamental aspects of physiological homeostasis and
behavior, including stress response, reproduction, growth, sleep, and feeding, several of …

The neuronal-specific SNORD115 has gathered interest because its deficiency may
contribute to the pathophysiology of Prader-Willi syndrome (PWS), possibly by altering post …

ABSTRACT The genetic disorder Prader-Willi syndrome (PWS) is mainly caused by the loss
of multiple paternally expressed genes in chromosome 15q11-q13 (the PWS region). Early …

Abstract Background Prader–Willi syndrome (PWS) is a rare and multisystemic genetic
disorder that is characterized by severe hypotonia, hyperphagia, short stature, and global …

Pseudouridylation is one of the most abundant RNA modifications in eukaryotes, making
pseudouridine known as the “fifth nucleoside.” This highly conserved alteration affects all …

Abstract Objective Prader‐Willi syndrome (PWS) is a multisystem genetic disorder.
Unfortunately, none of several mouse models carrying PWS mutations emulates the entirety …

Loss of expression of paternally imprinted genes in the 15q11. 2‐q13 chromosomal region
leads to the neurodevelopmental disorder Prader–Willi Syndrome (PWS). The PWS critical …