Pharmacokinetic and Pharmacodynamic Considerations of Antibiotic Use in Neonates
The selection of an appropriate dose of a given antibiotic for a neonate not only requires
knowledge of the drug's basic pharmacokinetic (PK) and pharmacodynamic (PD) properties …
knowledge of the drug's basic pharmacokinetic (PK) and pharmacodynamic (PD) properties …
Evaluation of neonatal and paediatric vancomycin pharmacokinetic models and the impact of maturation and serum creatinine covariates in a large multicentre data …
Abstract Background and Objective Infants and neonates present a clinical challenge for
dosing drugs with high interindividual variability due to these patients' rapid growth and the …
dosing drugs with high interindividual variability due to these patients' rapid growth and the …
[HTML][HTML] Population pharmacokinetics of vancomycin in very low birth weight neonates
A Alsultan, MF Al Munjem, KM Atiq, ZK Aljehani… - Frontiers in …, 2023 - frontiersin.org
Vancomycin dosing in very low birth weight (VLBW) neonates is challenging. Compared
with the general neonatal population, VLBW neonates are less likely to achieve the …
with the general neonatal population, VLBW neonates are less likely to achieve the …
Using population pharmacokinetics to optimize initial vancomycin dosing guidelines for neonates to treat sepsis caused by coagulase‐negative staphylococcus
E Chung, W Seto - … : The Journal of Human Pharmacology and …, 2023 - Wiley Online Library
Introduction Vancomycin dosing tailored for newborns is challenging due to the significant
influence of maturation and organ function on pharmacokinetics. Population …
influence of maturation and organ function on pharmacokinetics. Population …
Modeling the protein binding non-linearity in population pharmacokinetic model of valproic acid in children with epilepsy: a systematic evaluation study
L Zhang, M Liu, W Qin, D Shi, J Mao, Z Li - Frontiers in Pharmacology, 2023 - frontiersin.org
Background: Several studies have investigated the population pharmacokinetics (popPK) of
valproic acid (VPA) in children with epilepsy. However, the predictive performance of these …
valproic acid (VPA) in children with epilepsy. However, the predictive performance of these …
Model-informed precision dosing in vancomycin treatment
S Yoon, J Guk, SG Lee, D Chae, JH Kim… - Frontiers in …, 2023 - frontiersin.org
Introduction: While vancomycin remains a widely prescribed antibiotic, it can cause
ototoxicity and nephrotoxicity, both of which are concentration-associated. Overtreatment …
ototoxicity and nephrotoxicity, both of which are concentration-associated. Overtreatment …
Predicting treatment response to vancomycin using bacterial DNA load as a pharmacodynamic marker in premature and very low birth weight neonates: A population …
A Samb, R De Kroon, K Dijkstra… - Frontiers in …, 2023 - frontiersin.org
Background: While positive blood cultures are the gold standard for late-onset sepsis (LOS)
diagnosis in premature and very low birth weight (VLBW) newborns, these results can take …
diagnosis in premature and very low birth weight (VLBW) newborns, these results can take …
Improving Precision of Vancomycin Dosing in Neonatal Sepsis based on Clinical Outcome Evaluation and Population Pharmacokinetics
E Chung - 2023 - search.proquest.com
Background: Neonatal sepsis is commonly treated with vancomycin in the neonatal
intensive care unit (NICU). Vancomycin dosing remains a challenge in neonates due to …
intensive care unit (NICU). Vancomycin dosing remains a challenge in neonates due to …