[HTML][HTML] Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
[HTML][HTML] TGF-β signaling in health and disease
J Massagué, D Sheppard - Cell, 2023 - cell.com
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels
Cancer initiation and progression are likely caused by the dysregulation of biological
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells
persisting after curative intent therapy. The study of large patient cohorts incorporating …
persisting after curative intent therapy. The study of large patient cohorts incorporating …
Mechanisms driving the immunoregulatory function of cancer cells
A van Weverwijk, KE de Visser - Nature Reviews Cancer, 2023 - nature.com
Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …
activation state of immune cells, which impacts their progression and response to …
YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
[HTML][HTML] An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
The Hippo pathway is a key growth control pathway that is conserved across species. The
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …
[HTML][HTML] Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and
others have found that a subset of patients experiences paradoxical rapid cancer …
others have found that a subset of patients experiences paradoxical rapid cancer …