[HTML][HTML] Effects of shear stress on vascular endothelial functions in atherosclerosis and potential therapeutic approaches

H Cheng, W Zhong, L Wang, Q Zhang, X Ma… - Biomedicine & …, 2023 - Elsevier
Different blood flow patterns in the arteries can alter the adaptive phenotype of vascular
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …

[HTML][HTML] The beneficial and adverse effects of autophagic response to caloric restriction and fasting

R Shabkhizan, S Haiaty, MS Moslehian, A Bazmani… - Advances in …, 2023 - Elsevier
Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …

[HTML][HTML] SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells

N D'Onofrio, F Prattichizzo, R Marfella, C Sardu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (i) are a class
of lipid-lowering drugs suggested to hold a plethora of beneficial effects independent of their …

Tuning macrophages for atherosclerosis treatment

F Fang, C Xiao, C Li, X Liu, S Li - Regenerative Biomaterials, 2023 - academic.oup.com
Atherosclerosis is a chronic inflammatory vascular disease and a leading cause of death
worldwide. Macrophages play an important role in inflammatory responses, cell–cell …

Advances of nanomedicine in treatment of atherosclerosis and thrombosis

Y Mao, J Ren, L Yang - Environmental research, 2023 - Elsevier
Atherosclerosis (AS) is a chronic inflammatory vascular disease. Myocardial ischemia
originated from AS is the main cause of cardiovascular diseases, one of the major factors …

Trehalose-Bearing Carriers to Target Impaired Autophagy and Protein Aggregation Diseases

A Maruf, M Milewska, M Varga… - Journal of Medicinal …, 2023 - ACS Publications
In recent years, trehalose, a natural disaccharide, has attracted growing attention because of
the discovery of its potential to induce autophagy. Trehalose has also been demonstrated to …

Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis

Y Zhong, A Maruf, K Qu, M Milewska, I Wandzik… - Journal of …, 2023 - Springer
Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular
disease which is a leading cause of vascular diseases. During the progression of …

The expression of autophagy markers in IVIG-resistant Kawasaki disease and the establishment of prediction model

Y Zhou, Y Wu, C Yuan, W Yin, B Wang, Y Ding - BMC pediatrics, 2023 - Springer
Background The aim of this study was to find early predictors of Intravenous Immunoglobulin
(IVIG)-Resistant Kawasaki Disease. Methods Patients diagnosed with Kawasaki disease …

lncRNA TUG1 as potential novel biomarker for prognosis of cardiovascular diseases

H Haybar, NS Sadati, D Purrahman… - …, 2023 - Taylor & Francis
Globally, cardiovascular diseases (CVDs) are among the leading causes of death. In light of
the high prevalence and mortality of CVDs, it is imperative to understand the molecules …

The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its etiology, severity, and prognosis

C Lopez-Pedrera, R Oteros, A Ibáñez-Costa… - Journal of Thrombosis …, 2023 - Elsevier
Background Nowadays little is known about the molecular profile of the occluding thrombus
of patients with ischemic stroke. Objectives To analyze the proteomic profile of thrombi in …