[HTML][HTML] Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy
ZQ Wang, ZC Zhang, YY Wu, YN Pi, SH Lou… - Signal transduction and …, 2023 - nature.com
BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …
Gut microbiota‐derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling
LW Liu, Y Xie, GQ Li, T Zhang, YH Sui… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Gut microbiota dysbiosis induced by acute pancreatitis (AP)
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …
Assembly of mitochondrial succinate dehydrogenase in human health and disease
K Cao, J Xu, W Cao, X Wang, W Lv, M Zeng… - Free Radical Biology …, 2023 - Elsevier
Mitochondrial succinate dehydrogenase (SDH), also known as electron transport chain
(ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation …
(ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation …
qPTM: an updated database for PTM dynamics in human, mouse, rat and yeast
K Yu, Y Wang, Y Zheng, Z Liu, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Post-translational modifications (PTMs) are critical molecular mechanisms that regulate
protein functions temporally and spatially in various organisms. Since most PTMs are …
protein functions temporally and spatially in various organisms. Since most PTMs are …
[HTML][HTML] The role of altered protein acetylation in neurodegenerative disease
F Kabir, R Atkinson, AL Cook, AJ Phipps… - Frontiers in Aging …, 2023 - frontiersin.org
Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …
histone and non-histone proteins. It controls cellular processes such as DNA transcription …
Oligodendrocyte-derived transcellular signaling regulates axonal energy metabolism
S Li, ZH Sheng - Current opinion in neurobiology, 2023 - Elsevier
The unique morphology and functionality of central nervous system (CNS) neurons
necessitate specialized mechanisms to maintain energy metabolism throughout long axons …
necessitate specialized mechanisms to maintain energy metabolism throughout long axons …
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Histone deacetylases (HDACs) catalyse removal of acetyl groups from lysine residues on
both histone and non‐histone proteins to control numerous cellular processes. Of the 11 …
both histone and non‐histone proteins to control numerous cellular processes. Of the 11 …
Functional analysis of protein post‐translational modifications using genetic codon expansion
Post‐translational modifications (PTMs) of proteins not only exponentially increase the
diversity of proteoforms, but also contribute to dynamically modulating the localization …
diversity of proteoforms, but also contribute to dynamically modulating the localization …
Acetylation of inorganic pyrophosphatase by S-RNase signaling induces pollen tube tip swelling by repressing pectin methylesterase
Self-incompatibility (SI) is a widespread genetically determined system in flowering plants
that prevents self-fertilization to promote gene flow and limit inbreeding. S-RNase–based SI …
that prevents self-fertilization to promote gene flow and limit inbreeding. S-RNase–based SI …