Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …

Potato late blight caused by Phytophthora infestans is a devastating disease worldwide.
Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Nanotechnology has shown tremendous success in the drug delivery field for more effective
and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new …

Stereochemistry can alter small-molecule pharmacokinetics, safety and efficacy. However, it
is unclear whether the stereochemistry of a single compound within a multicomponent …

Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …

Multiple myeloma (MM), a hematologic malignancy that preferentially colonizes the bone
marrow, remains incurable with a survival rate of 3 to 6 mo for those with advanced disease …

Lipid nanoparticles (LNPs) are a clinically relevant way to deliver therapeutic mRNA to
hepatocytes in patients. However, LNP-mRNA delivery to end-stage solid tumors such as …