Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

Clinical evidence shows that intraocular hypertension is not the primary pathogenetic event
of glaucoma, whereas early neurodegeneration of retinal ganglion cells (RGCs) represents …

Objective: Periodontitis is a common chronic inflammatory disease in which oxidative stress
is one of the key pathogenic factors. Connexin43 (Cx43) is the most critical and widely …

To investigate the characteristics of mutation myocilin proteins and glaucoma pathological
phenotype in transgenic mice with full-length human Pro370Leu mutant myocilin gene (Tg …

The role of glia, particularly astrocytes, in mediating the central nervous system's response
to injury and neurodegenerative disease is an increasingly well studied topic. These cells …

Cell-to-cell communication through gap junction channels is very important to coordinate the
functions of cells in all multicellular biological tissues. It allows the direct exchange of ions …

There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

Introduction Identification of early adaptive and maladaptive neuronal stress responses is an
important step in developing targeted neuroprotective therapies for degenerative disease. In …

Neurodegeneration of the central nervous system (CNS) underscores many of humanity's
most debilitating diseases, including Alzheimer's disease, Parkinson's disease, and multiple …

Microglia are immune‐derived cells critical to the development and healthy function of the
brain and spinal cord, yet are implicated in the active pathology of many neuropsychiatric …