[HTML][HTML] Novel biomarkers used for early diagnosis and tyrosine kinase inhibitors as targeted therapies in colorectal cancer
H Jiang, S Zhou, G Li - Frontiers in pharmacology, 2023 - frontiersin.org
Colorectal cancer (CRC) is the third most common and second most lethal type of cancer
worldwide, presenting major health risks as well as economic costs to both people and …
worldwide, presenting major health risks as well as economic costs to both people and …
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …
[HTML][HTML] The dynamics of telomere length in primary and metastatic colorectal cancer lesions
M Kroupa, O Kubecek, K Tomasova, P Hanak… - Scientific Reports, 2023 - nature.com
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated
proteins, play a pivotal role in chromosome end protection and preservation of genomic …
proteins, play a pivotal role in chromosome end protection and preservation of genomic …
[HTML][HTML] Association of telomere length with colorectal cancer risk and prognosis: A systematic review and meta-analysis
S Pauleck, JA Sinnott, YL Zheng, SM Gadalla… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer risk and survival have previously been associated with
telomere length in peripheral blood leukocytes and tumor tissues. We quantitatively …
telomere length in peripheral blood leukocytes and tumor tissues. We quantitatively …
[HTML][HTML] Pathways Related to Colon Inflammation Are Associated with Colorectal Carcinoma: A Transcriptome-and Methylome-Wide Study
MG Kibriya, F Jasmine, J Pekow, A Munoz, C Weber… - Cancers, 2023 - mdpi.com
Simple Summary Colon cancer is one of the common cancers affecting a large number of
patients globally. In sporadic CRC, several genetic factors may play important roles such as …
patients globally. In sporadic CRC, several genetic factors may play important roles such as …
[HTML][HTML] Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
M Falcinelli, G Dell'Omo, E Grassi, E Mariella… - Cell Death & …, 2023 - nature.com
Telomere maintenance is necessary to maintain cancer cell unlimited viability. However, the
mechanisms maintaining telomere length in colorectal cancer (CRC) have not been …
mechanisms maintaining telomere length in colorectal cancer (CRC) have not been …
Leukocyte telomere length and mitochondrial DNA copy number association with colorectal cancer risk in an aging population
S Malyutina, V Maximov, O Chervova… - Global Translational …, 2023 - discovery.ucl.ac.uk
In this study, we evaluated the association of blood leukocyte telomere length (LTL) and
mitochondrial DNA copy number (mtDNA-CN) with the risk of incident colorectal cancer …
mitochondrial DNA copy number (mtDNA-CN) with the risk of incident colorectal cancer …
Development and treatment of colorectal cancer: Insights from multi‐kingdom microbiota
YM Hong, D Song, NN Liu, H Wang - Aging and Cancer, 2023 - Wiley Online Library
Colorectal cancer (CRC) is a multistage and highly heterogeneous malignant disease that
mostly occurred in aged people accompanied by microbiota alteration. Emerging evidence …
mostly occurred in aged people accompanied by microbiota alteration. Emerging evidence …