Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are ubiquitously expressed large-
conductance Ca 2+-permeable channels predominantly localized to the endoplasmic …

Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant
treatment-related morbidity. It is vital to discover effective, minimally invasive therapies that …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) are endoplasmic reticulum Ca2+
channels whose biphasic dependence on cytosolic Ca2+ gives rise to Ca2+ oscillations that …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are ER Ca 2+-release channels
that control a broad set of cellular processes. Animal models lacking IP 3 Rs in different …

Intracellular Ca 2+ signals play a vital role in a broad range of cell biological and
physiological processes in all eukaryotic cell types. Dysregulation of Ca 2+ signaling has …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are large tetrameric channels
which sit mostly in the membrane of the endoplasmic reticulum (ER) and mediate Ca 2+ …

Ca 2+ puffs are brief, localized Ca 2+ signals evoked by physiological stimuli that arise from
the coordinated opening of a few clustered inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) …

Formaldehyde (FA), which is known as an air pollutant, has been proven to induce male
infertility. However, the underlying mechanism of FA-induced male infertility remains elusive …

Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-
operated calcium (Ca2+) entry resulting in severe immunodeficiency. The inositol 1, 4, 5 …