Abstract Purpose of Review Leptomeningeal disease (LMD) is a devastating complication of
advanced metastatic cancer associated with a poor prognosis and limited treatment options …

Leptomeningeal metastases represent an aggressive stage of cancer with few durable
treatment options. Improved understanding of cancer biology, neoplastic reliance on …

Current Treatment Options in Oncology edema. Stereotactic radiosurgery offers a benefit
over whole‑brain radiation attributed to the relative radioresistance of melanoma and …

Abstract Purpose of Review Headaches are a common, oftentimes debilitating symptom in
patients with leptomeningeal metastases. Recent Findings The third edition of the …

Novel approaches to treatment of leptomeningeal metastases : Current Opinion in Neurology
Novel approaches to treatment of leptomeningeal metastases : Current Opinion in Neurology …

Aims/purpose: Leptomeningeal metastases (LM) are associated with substantial morbidity
and mortality. Several approaches are used to treat LM, including intrathecally administered …

Abstract Purpose of Review Breast cancer with brain metastasis (BCBM) and
leptomeningeal disease (LMD) are important clinical problems. Traditionally, patients with …

Simple Summary Leptomeningeal carcinomatosis is a devastating complication of solid
malignancies and can occur concurrently in patients with brain metastasis. Despite progress …

Purpose To outline the dose rationale for the first in-human intrathecal delivery of
bevacizumab for LMS of GBM. Methods A 19-year-old female patient presented to Lenox Hill …

Purpose To explore the impact of intrathecal pemetrexed (IP) on the survival of lung
adenocarcinoma (LUAC) patients with leptomeningeal metastasis (LM). Methods We …