Immune checkpoint blockade is a compelling approach in tumor immunotherapy. Blocking
inhibitory pathways in T cells has demonstrated clinical efficacy in different types of cancer …

Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate
immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are …

We report herein an exploratory biomarker analysis of refractory tumors collected from
pediatric patients before atezolizumab therapy (iMATRIX-atezolizumab, NCT02541604) …

Aplastic anemia (AA) is a lethal hematological disorder; however, its pathogenesis is not
fully understood. Although immunosuppressive therapy (IST) is a major treatment option for …

Simple Summary Tumor immunogenicity is one of the main factors influencing responses to
cancer therapies and long-lasting antitumoral immunity. In this review, we will cover how …

Many specificities single out HLA‐F: its structure, expression regulation at cell membrane
and function. HLA‐F mRNA is detected in the most cell types and the protein is localized in …

Das Immunsystem ist in der Lage, körpereigene entartete Zellen zu erkennen und zu
eliminieren. Die Identifizierung der körpereigenen Zellen, Erkennung von entarteten Zellen …

Assisted reproduction techniques (ART) have undergone a significant expansion in the last
decades. Indeed, the number of in vitro fertilization (IVF) cycles has multiplied in the United …

HLA-F is a non classical HLA-I molecule that can be a strong activating trigger for highly
cytotoxic natural killer (NK) cells when upregulated on virus-infected target cells. HLA-F …

Class I HLA molecules “present” short peptide antigens to NK and T cell receptors to convert
intracellular information into an extracellular immune response. These molecules are …