Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

The future of precision medicine in the cure of Alzheimer's disease

A Arafah, S Khatoon, I Rasool, A Khan, MA Rather… - Biomedicines, 2023 - mdpi.com
This decade has seen the beginning of ground-breaking conceptual shifts in the research of
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …

Fluorine-18-Labeled Diaryl-Azines as Improved β-Amyloid Imaging Tracers: From Bench to First-in-Human Studies

Y Li, K Zhou, X Zhang, H Zhao, X Wang… - Journal of Medicinal …, 2023 - ACS Publications
The deposition of β-amyloid (Aβ) in the brain is a pathologic hallmark of Alzheimer's disease
(AD), appearing years before the onset of symptoms, and its detection is incorporated into …

Improving Alzheimer's disease diagnosis with multi-modal PET embedding features by a 3D multi-task MLP-mixer neural network

ZC Zhang, X Zhao, G Dong… - IEEE Journal of …, 2023 - ieeexplore.ieee.org
Positron emission tomography (PET) with fluorodeoxyglucose (FDG) or florbetapir (AV45)
has been proved effective in the diagnosis of Alzheimer's disease. However, the expensive …

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

HY Kim, WK Chia, CJ Hsieh… - Journal of Medicinal …, 2023 - ACS Publications
Abnormal α-synuclein (α-syn) aggregation characterizes α-synucleinopathies, including
Parkinson's disease (PD) and multiple system atrophy (MSA). However, no suitable positron …

International nuclear medicine consensus on the clinical use of amyloid positron emission tomography in Alzheimer's disease

M Tian, C Zuo, AC Civelek, I Carrio, Y Watanabe… - Phenomics, 2023 - Springer
Alzheimer's disease (AD) is the main cause of dementia, with its diagnosis and management
remaining challenging. Amyloid positron emission tomography (PET) has become …

[PDF][PDF] Neuroimaging in Alzheimer's disease for early diagnosis: a comprehensive review

S Aramadaka, R Mannam, RS Narayanan, A Bansal… - Cureus, 2023 - cureus.com
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting
roughly half of those over the age of 85. We briefly discussed the risk factors, epidemiology …

Brain networks, clinical manifestations, and neuroimaging of cognitive disorders: The role of computed tomography (CT), magnetic resonance imaging (MRI), positron …

B Bonakdarpour, C Takarabe - Clinics in Geriatric Medicine, 2023 - geriatric.theclinics.com
Individuals with neurocognitive disorders present with problems of memory loss, language
impairment, visuospatial difficulties, perceptual abnormalities, apraxias, attention/executive …

Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly …

CD Chen, A McCullough, B Gordon… - European journal of …, 2023 - Springer
Abstract Purpose Pittsburgh Compound-B (11C-PiB) and 18F-florbetapir are amyloid-β (Aβ)
positron emission tomography (PET) radiotracers that have been used as endpoints in …

An Angkor nation? Identifying the core of the Khmer empire

I Lowman, C Kunthea, M Hendrickson - The Angkorian World, 2023 - taylorfrancis.com
While the rulers of Angkor projected their power to varying degrees throughout central and
eastern mainland Southeast Asia, their most significant achievement was creating and …