Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Cellular senescence within the cardiovascular system has, until recently, been understudied
and unappreciated as a factor in the development of age‐related cardiovascular diseases …

Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular
matrix and orchestrates a damage response to maintain cardiac architecture and …

Organ fibrosis represents a dysregulated, maladaptive wound repair response that results in
progressive disruption of normal tissue architecture leading to detrimental deterioration in …

Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now
standard therapy, pathological remodelling leading to heart failure remains a clinical …

During ageing molecular damage leads to the accumulation of several hallmarks of ageing
including mitochondrial dysfunction, cellular senescence, genetic instability and chronic …

Atrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the
potential molecular mechanism is not clear. Acetyltransferase p300 participates in the …

Cellular senescence leads to decreased tissue regeneration and inflammation and is
associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the …