Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …

The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …

Following the recent review by Merikangas et al.[1] summarizing differential gene
expression in schizophrenia, we wanted to provide readers with our perspective on the state …

Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …

Parkinson＇ s disease (PD) is a progressive neurodegenerative disorder characterized by
both motor and non-motor symptoms. Aggravation of symptoms is mirrored by accumulation …

Oxford Nanopore direct RNA sequencing (DRS) is capable of sequencing complete RNA
molecules and accurately measuring gene and isoform expression. However, as DRS is …

Self-organized blastoids from extended pluripotent stem (EPS) cells possess enormous
potential for investigating postimplantation embryo development and related diseases …

Ancestral differences in genomic variation are determining factors in gene regulation;
however, most gene expression studies have been limited to European ancestry samples or …

For over a century, brain research narrative has mainly centered on neuron cells.
Accordingly, most whole-brain neurodegenerative studies focus on neuronal dysfunction …

Availability of molecularly intact biospecimens is essential in genetic diagnostics to obtain
credible results. Integrity of nucleic acids (particularly RNA) may be compromised at various …