Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling
pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that …

Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

In the working-age population worldwide, diabetic retinopathy (DR), a prevalent
complication of diabetes, is the main cause of vision impairment. Chronic low-grade …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged
as the most common form of dementia in the elderly. Several pathological hallmarks have …

We are witnessing the globalization of a specific type of arteriosclerosis with rising
prevalence, incidence and an overall cardiovascular disease burden. Currently …

Background The impairment in the autophagy-lysosomal pathway (ALP) and the activation
of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular …