Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
The Inseparable Relationship Between Cholesterol and Hedgehog Signaling
Ligands of the Hedgehog (HH) pathway are paracrine signaling molecules that coordinate
tissue development in metazoans. A remarkable feature of HH signaling is the repeated use …
tissue development in metazoans. A remarkable feature of HH signaling is the repeated use …
[HTML][HTML] Hedgehog signaling in gonadal development and function
I Dilower, AJ Niloy, V Kumar, A Kothari, EB Lee… - Cells, 2023 - mdpi.com
Three distinct hedgehog (HH) molecules,(sonic, desert, and indian), two HH receptors
(PTCH1 and PTCH2), a membrane bound activator (SMO), and downstream three …
(PTCH1 and PTCH2), a membrane bound activator (SMO), and downstream three …
[HTML][HTML] The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis
F Gude, J Froese, G Steffes… - Biochemical Society …, 2023 - portlandpress.com
Patterns of gene expression, cell growth and cell-type specification during development are
often regulated by morphogens. Morphogens are signalling molecules produced by groups …
often regulated by morphogens. Morphogens are signalling molecules produced by groups …
[HTML][HTML] SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1
T Qiu, L Hou, L Zhao, X Wang, Z Zhou, C Yang… - Journal of Biological …, 2023 - ASBMB
Breast cancer stem cells are mainly responsible for poor prognosis, especially in triple-
negative breast cancer (TNBC). In a previous study, we demonstrated that ε-Sarcoglycan …
negative breast cancer (TNBC). In a previous study, we demonstrated that ε-Sarcoglycan …
Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad
G Deshpande, C Ng, N Jourjine, JW Chiew, J Dasilva… - Genetics, 2023 - academic.oup.com
In addition to inducing nonautonomous specification of cell fate in both Drosophila and
vertebrates, the Hedgehog pathway guides cell migration in a variety of different tissues …
vertebrates, the Hedgehog pathway guides cell migration in a variety of different tissues …
Ihog proteins contribute to integrin-mediated focal adhesions
Y Qi, H Liu, K Zhang, Y Wu, C Shen, X Lin - Science China Life Sciences, 2023 - Springer
Integrin expression forms focal adhesions, but how this process is physiologically regulated
is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling …
is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling …
[HTML][HTML] CDON contributes to Hedgehog-dependent patterning and growth of the developing limb
ML Echevarría-Andino, NE Franks, HE Schrader… - Developmental …, 2023 - Elsevier
Hedgehog (HH) signaling is a major driver of tissue patterning during embryonic
development through the regulation of a multitude of cell behaviors including cell fate …
development through the regulation of a multitude of cell behaviors including cell fate …
Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish
The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling
during vertebrate development. Recent work showing roles for these genes in axon …
during vertebrate development. Recent work showing roles for these genes in axon …
[PDF][PDF] Hedgehog Signaling in Gonadal Development and Function. Cells 2023, 12, 358
Three distinct hedgehog (HH) molecules,(sonic, desert, and indian), two HH receptors
(PTCH1 and PTCH2), a membrane bound activator (SMO), and downstream three …
(PTCH1 and PTCH2), a membrane bound activator (SMO), and downstream three …