Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …

Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via
its influence on immunity and metabolism, caloric restriction and fasting appear to be …

Immune checkpoint inhibitors cause side effects ranging from autoimmune endocrine
disorders to severe cardiotoxicity. Periodic Fasting mimicking diet (FMD) cycles are …

Maladaptive, non-resolving inflammation contributes to chronic inflammatory diseases such
as atherosclerosis. Because macrophages remove necrotic cells, defective macrophage …

Introduction High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD)
by promoting chronic inflammation. However, the mechanisms are poorly understood …

Experimental trials in organisms ranging from yeast to humans have shown that various
forms of reducing food intake (caloric restriction) appear to increase both overall and healthy …

Mild or transient dietary restriction (DR) improves many aspects of health and aging.
Emerging evidence from us and others has demonstrated that DR also optimizes the …

Obesity is one of the most serious global health problems, with an incidence that increases
yearly and coincides with the development of cancer. Adipose tissue macrophages (ATMs) …

Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …