Duchenne muscular dystrophy: pathogenesis and promising therapies
M Chang, Y Cai, Z Gao, X Chen, B Liu, C Zhang… - Journal of …, 2023 - Springer
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease,
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …
Regulation of satellite cells functions during skeletal muscle regeneration: a critical step in physiological and pathological conditions
G Careccia, L Mangiavini, F Cirillo - International Journal of Molecular …, 2023 - mdpi.com
Skeletal muscle regeneration is a complex process involving the generation of new
myofibers after trauma, competitive physical activity, or disease. In this context, adult skeletal …
myofibers after trauma, competitive physical activity, or disease. In this context, adult skeletal …
Mechanisms and effects of metformin on skeletal muscle disorders
R Shang, J Miao - Frontiers in Neurology, 2023 - frontiersin.org
Skeletal muscle disorders are mostly genetic and include several rare diseases. With
disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The …
disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The …
Longitudinal assessment of skeletal muscle functional mechanics in the DE50-MD dog model of Duchenne muscular dystrophy
DO Riddell, JCW Hildyard, R Harron… - Disease Models & …, 2023 - journals.biologists.com
Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin (DMD) gene,
is associated with fatal muscle degeneration and atrophy. Patients with DMD have …
is associated with fatal muscle degeneration and atrophy. Patients with DMD have …
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal
protein essential for the preservation of the structural integrity of the muscle cell membrane …
protein essential for the preservation of the structural integrity of the muscle cell membrane …
Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms
The absence of dystrophin hypersensitizes skeletal muscle of lower and higher vertebrates
to eccentric contraction (ECC)-induced strength loss. Loss of strength can be accompanied …
to eccentric contraction (ECC)-induced strength loss. Loss of strength can be accompanied …
Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse
L Duvick, WM Southern, K Benzow, ZN Burch… - bioRxiv, 2023 - biorxiv.org
ABSTRACT Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease
caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To …
caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To …
Accumulation of Dystrophin-Positive Muscle Fibers and Improvement of Neuromuscular Junctions in mdx Mouse Muscles after Bone Marrow Transplantation under …
AV Sokolova, AP Domnina, VM Mikhailov - International Journal of …, 2023 - mdpi.com
Duchenne muscular dystrophy (DMD) is a severe muscular disorder caused by mutations in
the dystrophin gene. It leads to respiratory and cardiac failure and premature death at a …
the dystrophin gene. It leads to respiratory and cardiac failure and premature death at a …
Ltbp complex-specific inhibitors of tgfb1 and uses thereof
T Schurpf, G CORICOR, JW JACKSON, A POLZIN - 2023 - Google Patents
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-
amino-3-phenylpropanoyl] amino]-3-phenylpropanoyl] amino]-4-methylpentanoyl] amino] …
amino-3-phenylpropanoyl] amino]-3-phenylpropanoyl] amino]-4-methylpentanoyl] amino] …
TGFβ1-binding immunoglobulins and use thereof
T Schurpf, GJ Carven, A Datta, K Long - US Patent 11,643,459, 2023 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
58503696&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
58503696&utm_source= google_patent&utm_medium= platform_link&utm_campaign …