Duchenne muscular dystrophy: pathogenesis and promising therapies

M Chang, Y Cai, Z Gao, X Chen, B Liu, C Zhang… - Journal of …, 2023 - Springer
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease,
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …

Regulation of satellite cells functions during skeletal muscle regeneration: a critical step in physiological and pathological conditions

G Careccia, L Mangiavini, F Cirillo - International Journal of Molecular …, 2023 - mdpi.com
Skeletal muscle regeneration is a complex process involving the generation of new
myofibers after trauma, competitive physical activity, or disease. In this context, adult skeletal …

Mechanisms and effects of metformin on skeletal muscle disorders

R Shang, J Miao - Frontiers in Neurology, 2023 - frontiersin.org
Skeletal muscle disorders are mostly genetic and include several rare diseases. With
disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The …

Longitudinal assessment of skeletal muscle functional mechanics in the DE50-MD dog model of Duchenne muscular dystrophy

DO Riddell, JCW Hildyard, R Harron… - Disease Models & …, 2023 - journals.biologists.com
Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin (DMD) gene,
is associated with fatal muscle degeneration and atrophy. Patients with DMD have …

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

D Hahn, JD Quick, BR Thompson, A Crabtree… - Skeletal muscle, 2023 - Springer
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal
protein essential for the preservation of the structural integrity of the muscle cell membrane …

Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms

L Kiriaev, CW Baumann, A Lindsay - Journal of General Physiology, 2023 - rupress.org
The absence of dystrophin hypersensitizes skeletal muscle of lower and higher vertebrates
to eccentric contraction (ECC)-induced strength loss. Loss of strength can be accompanied …

Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse

L Duvick, WM Southern, K Benzow, ZN Burch… - bioRxiv, 2023 - biorxiv.org
ABSTRACT Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease
caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To …

Accumulation of Dystrophin-Positive Muscle Fibers and Improvement of Neuromuscular Junctions in mdx Mouse Muscles after Bone Marrow Transplantation under …

AV Sokolova, AP Domnina, VM Mikhailov - International Journal of …, 2023 - mdpi.com
Duchenne muscular dystrophy (DMD) is a severe muscular disorder caused by mutations in
the dystrophin gene. It leads to respiratory and cardiac failure and premature death at a …

Ltbp complex-specific inhibitors of tgfb1 and uses thereof

T Schurpf, G CORICOR, JW JACKSON, A POLZIN - 2023 - Google Patents
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-
amino-3-phenylpropanoyl] amino]-3-phenylpropanoyl] amino]-4-methylpentanoyl] amino] …

TGFβ1-binding immunoglobulins and use thereof

T Schurpf, GJ Carven, A Datta, K Long - US Patent 11,643,459, 2023 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
58503696&utm_source= google_patent&utm_medium= platform_link&utm_campaign …