Globally, depression is a leading cause of disability and has remained so for decades.
Antidepressant medications have suboptimal outcomes and are too frequently associated …

Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …

Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and
oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential …

Data on incidence, prevalence and burden of ADHD are crucial for clinicians, patients, and
stakeholders. We present the incidence, prevalence, and burden of ADHD globally and …

Dental caries is one of the most prevalent human diseases resulting from tooth
demineralization caused by acid production of bacteria plaque. It remains challenges for …

Glaucoma is a chronic neuro-degenerative condition that is one of the world's leading
causes of irreversible but preventable blindness. The blindness is generally caused by the …

Dilated cardiomyopathy (DCM) is typically defined by left ventricular dilation and systolic
dysfunction in the absence of a clear precipitant. Idiopathic disease is common; up to 50% of …

This systematic review identified various bioactive compounds which have the potential to
serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia …

Objectives: Previous meta-analyses of a small number of trials showed that acceptance and
commitment therapy (ACT) might improve chronic pain. Many new trials have been …

Mindfulness-based programs (MBPs) are widely used to prevent mental ill health. Evidence
suggests beneficial average effects but wide variability. We aimed to confirm the effect of …