Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Importance Approximately 5% of all primary care visits in adults are related to knee pain.
Osteoarthritis (OA), patellofemoral pain, and meniscal tears are among the most common …

Data on incidence, prevalence and burden of ADHD are crucial for clinicians, patients, and
stakeholders. We present the incidence, prevalence, and burden of ADHD globally and …

Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and
oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential …

Psychiatric disorders are now responsible for the largest proportion of the global burden of
disease, and even more challenges have been seen during the COVID-19 pandemic …

Importance Prehabilitation programs for patients undergoing orthopedic surgery have been
gaining popularity in recent years. However, the current literature has produced varying …

Globally, depression is a leading cause of disability and has remained so for decades.
Antidepressant medications have suboptimal outcomes and are too frequently associated …

Progression of chronic liver disease is precipitated by hepatocyte loss, inflammation and
fibrosis. This process results in the loss of critical hepatic functions, increasing morbidity and …

Objective The objective of this study was to aggregate data for the first genomewide
association study meta‐analysis of cluster headache, to identify genetic risk variants, and …

Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …