Risk-stratified therapy for pediatric acute myeloid leukemia

D Tomizawa, SI Tsujimoto - Cancers, 2023 - mdpi.com
Simple Summary Owing to the 40-year worldwide efforts for improving diagnosis and
therapy for acute myeloid leukemia (AML), the second most common type of leukemia in …

Recent updates in venetoclax combination therapies in pediatric hematological malignancies

M Leśniak, J Lipniarska, P Majka, M Lejman… - International Journal of …, 2023 - mdpi.com
Venetoclax is a strongly effective B-cell lymphoma-2 inhibitor (BCL-2) with an ability to
selectively restore the apoptotic potential of cancerous cells. It has been proven that in …

Children's Oncology Group's 2023 blueprint for research: Myeloid neoplasms

TM Cooper, TA Alonzo, SK Tasian… - Pediatric Blood & …, 2023 - Wiley Online Library
During the past decade, the outcomes of pediatric patients with acute myeloid leukemia
(AML) have plateaued with 5‐year event‐free survival (EFS) and overall survival (OS) of …

A Review of Childhood Acute Myeloid Leukemia: Diagnosis and Novel Treatment

S Tseng, ME Lee, PC Lin - Pharmaceuticals, 2023 - mdpi.com
Acute myeloid leukemia (AML) is the second most common hematologic malignancy in
children. The incidence of childhood AML is much lower than acute lymphoblastic leukemia …

Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expression

KL Juul-Dam, NN Shukla, TM Cooper… - European Journal of …, 2023 - Elsevier
Despite advances in the clinical management of childhood acute myeloid leukemia (AML)
during the last decades, outcome remains fatal in approximately one third of patients …

Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia: an I-BFM Study Group collaboration

ASB Hammer, KL Juul-Dam, JD Sandahl… - Blood …, 2023 - ashpublications.org
Hypodiploidy, defined as modal numbers (MNs) 45 or lower, has not been independently
investigated in pediatric acute myeloid leukemia (AML) but is a well-described high-risk …

[HTML][HTML] Proposal of a new genomic framework for categorization of pediatric acute myeloid leukemia associated with prognosis

M Umeda, J Ma, T Westover, Y Ni, G Song… - Research …, 2023 - ncbi.nlm.nih.gov
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Cytogenetics in the management of acute myeloid leukemia and histiocytic/dendritic cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique …

A Bidet, J Quessada, W Cuccuini, M Decamp… - Current Research in …, 2023 - Elsevier
Genetic data are becoming increasingly essential in the management of hematological
neoplasms as shown by two classifications published in 2022: the 5th edition of the World …

Younger age and induction failure predict outcomes in infant leukemia: 30 years of experience in a tertiary center

B Ochoa-Fernández, V Galán-Gómez… - Frontiers in …, 2023 - frontiersin.org
Objectives This study aimed to evaluate the characteristics and outcomes of infant patients
with leukemia. Methods A retrospective analysis was conducted in a cohort of 39 patients …

Measurable residual disease study through three different methods can anticipate relapse and guide pre-emptive therapy in childhood acute myeloid leukemia

E Ramos Elbal, JL Fuster, JA Campillo… - Clinical and …, 2023 - Springer
Purpose Although outcomes of children with acute myeloid leukemia (AML) have improved
over the last decades, around one-third of patients relapse. Measurable (or minimal) …