The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis

B Sossen, AS Richards, T Heinsohn… - The Lancet …, 2023 - thelancet.com
Stages of tuberculosis disease can be delineated by radiology, microbiology, and
symptoms, but transitions between these stages remain unclear. In a systematic review and …

Cardiovascular involvement in tuberculosis: from pathophysiology to diagnosis and complications—a narrative review

DTM Marcu, CA Adam, F Mitu, C Cumpat… - Diagnostics, 2023 - mdpi.com
Although primarily a lung disease, extra-pulmonary tuberculosis (TB) can affect any organ or
system. Of these, cardiovascular complications associated with disease or drug toxicity …

Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys

JC Emery, PJ Dodd, S Banu, B Frascella, FL Garden… - Elife, 2023 - elifesciences.org
Background: Individuals with bacteriologically confirmed pulmonary tuberculosis (TB)
disease who do not report symptoms (subclinical TB) represent around half of all prevalent …

Beyond latent and active tuberculosis: a scoping review of conceptual frameworks

SMA Zaidi, AK Coussens, JA Seddon, T Kredo… - …, 2023 - thelancet.com
There is growing recognition that tuberculosis (TB) infection and disease exists as a
spectrum of states beyond the current binary classification of latent and active TB. Our aim …

Reevaluating progression and pathways following Mycobacterium tuberculosis infection within the spectrum of tuberculosis

KC Horton, AS Richards, JC Emery… - Proceedings of the …, 2023 - National Acad Sciences
Traditional understanding of the risk of progression from Mycobacterium tuberculosis (Mtb)
infection to tuberculosis (TB) overlooks diverse presentations across a spectrum of disease …

Treatment for radiographically active, sputum culture-negative pulmonary tuberculosis: A systematic review and meta-analysis

AT Gray, L Macpherson, F Carlin, B Sossen… - PLoS …, 2023 - journals.plos.org
Background People with radiographic evidence for pulmonary tuberculosis (TB), but
negative sputum cultures, have increased risk of developing culture-positive TB. Recent …

Genetic polymorphism related to ethambutol outcomes and susceptibility to toxicity

MI Barliana, NN Afifah, V Yunivita, R Ruslami - Frontiers in Genetics, 2023 - frontiersin.org
The World Health Organization (WHO) stated that ensuring access to effective and optimal
treatment is a key component to eradicate tuberculosis (TB) through the End TB Strategy …

How We Treat Drug-Susceptible Pulmonary Tuberculosis: A Practical Guide for Clinicians

N Riccardi, S Occhineri, E Vanino, RM Antonello… - Antibiotics, 2023 - mdpi.com
Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide
and pulmonary TB (PTB) is the main variant responsible for fueling transmission of the …

Beyond latent and active–a scoping review of conceptual frameworks and diagnostic criteria for tuberculosis

SMA Zaidi, AK Coussens, JA Seddon, T Kredo… - medRxiv, 2023 - medrxiv.org
Background There is growing recognition that tuberculosis (TB) infection and disease exists
as a spectrum of states beyond the current binary classification of latent and active TB. Our …

Treatment of Infection as a Core Strategy to Prevent Rifampicin-Resistant/Multidrug-Resistant Tuberculosis

A Reuter, J Furin - Pathogens, 2023 - mdpi.com
An estimated 19 million people are infected with rifampicin-resistant/multidrug-resistant
strains of tuberculosis worldwide. There is little done to prevent these individuals from …