Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

The mechanisms that confer cognitive resilience to Alzheimer's Disease (AD) are not fully
understood. Here, we describe a neural circuit mechanism underlying this resilience in a …

In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …

It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease
(AD), first accumulates cortically in the default mode network (DMN), years before AD …

Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …

One of the hallmarks of Alzheimer's disease (AD) is structural cell damage and neuronal
death in the brains of affected individuals. As these changes are irreversible, it is important …

Amyloid precursor protein (APP) internalization via clathrin-/dynamin-mediated endocytosis
(CME) mediated by its YENPTY motif into endosomes containing β-secretase is proposed to …

Neurological diseases including Alzheimer's, Huntington's disease, Parkinson's disease,
Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are …

Learning and memory storage are the fundamental activities of the brain. Aberrant
expression of synaptic molecular markers has been linked to memory impairment in AD …