Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Conserved genomic sequences disrupted in humans may underlie uniquely human
phenotypic traits. We identified and characterized 10,032 human-specific conserved …

Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

There are marked sex differences in the prevalence, phenotypic presentation and treatment
response for major depression. While genome-wide association studies (GWAS) adjust for …

A potential relationship between dysregulation of immune/inflammatory pathways and
cognitive impairment has been suggested in severe mental illnesses (SMI), such as …

Objective: Altered levels of peripheral inflammatory and proinflammatory cytokine markers
affect the different clinical stages of major depressive disorder (MDD). A concrete …

Circulating levels of the astrocytic marker S100B have been associated with risk of
neuropsychiatric or neurological disorders. However, reported effects have been …

Advances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated
functional interpretation of disease-associated variants discovered from genome-wide …

Schizophrenia is a psychiatric disorder that results from genetic and environmental factors
interacting and disrupting neurodevelopmental trajectories. Human Accelerated Regions …