Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins
MN Gupta, VN Uversky - International Journal of Biological Macromolecules, 2023 - Elsevier
Abstract Arginine shows Jekyll and Hyde behavior in several respects. It participates in
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …
Messenger RNA translation defects in neurodegenerative diseases
E Storkebaum, K Rosenblum… - New England Journal of …, 2023 - Mass Medical Soc
Messenger RNA Translation Defects in Neurodegenerative Diseases | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
Amyotrophic lateral sclerosis and frontotemporal dementia patients with a hexanucleotide
repeat expansion in C9ORF72 (C9-HRE) accumulate poly-GR and poly-PR aggregates. The …
repeat expansion in C9ORF72 (C9-HRE) accumulate poly-GR and poly-PR aggregates. The …
The need for biomarkers in the ALS–FTD spectrum: a clinical point of view on the role of proteomics
F Vignaroli, A Mele, G Tondo, V De Giorgis, M Manfredi… - Proteomes, 2023 - mdpi.com
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are severely
debilitating and progressive neurodegenerative disorders. A distinctive pathological feature …
debilitating and progressive neurodegenerative disorders. A distinctive pathological feature …
Transcriptome-wide RNA binding analysis of C9orf72 poly (PR) dipeptides
R Balendra, IR de Los Mozos, HM Odeh… - Life Science …, 2023 - life-science-alliance.org
An intronic GGGGCC repeat expansion in C9orf72 is a common genetic cause of
amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in …
amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in …
Translation dysregulation in neurodegenerative diseases: a focus on ALS
RNA translation is tightly controlled in eukaryotic cells to regulate gene expression and
maintain proteome homeostasis. RNA binding proteins, translation factors, and cell …
maintain proteome homeostasis. RNA binding proteins, translation factors, and cell …
CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis
K Kume, T Kurashige, K Muguruma, H Morino… - The American Journal of …, 2023 - cell.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons. Although repeat expansion in C9orf72 is its most common …
degeneration of motor neurons. Although repeat expansion in C9orf72 is its most common …
[HTML][HTML] Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease
Positively charged repeat peptides are emerging as key players in neurodegenerative
diseases. These peptides can perturb diverse cellular pathways but a unifying framework for …
diseases. These peptides can perturb diverse cellular pathways but a unifying framework for …
Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate
Hexanucleotide expansion mutations in C9ORF72 are a frequent cause of amyotrophic
lateral sclerosis. We previously reported that long arginine-rich dipeptide repeats (DPRs) …
lateral sclerosis. We previously reported that long arginine-rich dipeptide repeats (DPRs) …
Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges
Arginine-rich dipeptide repeat proteins (R-DPRs), poly (PR) and poly (GR), translated from
the hexanucleotide repeat expansion in the amyotrophic lateral sclerosis (ALS)-causative …
the hexanucleotide repeat expansion in the amyotrophic lateral sclerosis (ALS)-causative …