The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF)
continue to rise in tandem with the increasing age and burdens of obesity, sedentariness …

Iron deficiency (ID) is common in patients with cardiovascular disease. Up to 60% of patients
with coronary artery disease, and an even higher proportion of those with heart failure (HF) …

In patients with heart failure, sodium-glucose cotransporter 2 (SGLT2) inhibitors have been
shown to decrease hepcidin and ferritin and increase transferrin receptor protein, changes …

Background: Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately
involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) is a pattern recognition …

Background: Inflammation may play a role in the pathophysiology of heart failure with
preserved ejection fraction. We examined whether circulating levels of interleukin-6 identify …

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

Abstract Background Interleukin (IL)-6 is a central inflammatory mediator and potential
therapeutic target in heart failure (HF). Prior studies have shown that IL-6 concentrations are …

Abstract Aims Interleukin-6 (IL-6) and interleukin-18 (IL-18), important cytokines implicated
in atherosclerosis and inflammaging, were assessed for associations with global …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Mice fully deficient in peptidylarginine deiminase 4 (PAD4) enzyme have preserved cardiac
function and reduced collagen deposition during ageing. The cellular source of PAD4 is …