An overview of DNA methylation-derived trait score methods and applications
Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …
thousands of individuals. These studies typically test the associations between individual …
Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
J Perez-Garcia, M Pino-Yanes, EG Plender… - Clinical …, 2023 - Springer
Background Albuterol is the first-line asthma medication used in diverse populations.
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …
Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure
W Wang, J Yao, W Li, Y Wu, H Duan, C Xu, X Tian… - Clinical …, 2023 - Springer
Background Hypertension is a crucial risk factor for developing cardiovascular disease and
reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially …
reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially …
DNA methylation modulated genetic variant effect on gene transcriptional regulation
Background Expression quantitative trait locus (eQTL) analysis has emerged as an
important tool in elucidating the link between genetic variants and gene expression, thereby …
important tool in elucidating the link between genetic variants and gene expression, thereby …
Genome‐wide DNA methylation analysis of body composition in Chinese monozygotic twins
H Tian, H Qiao, F Han, X Kong, S Zhu… - European Journal of …, 2023 - Wiley Online Library
Background Little is currently known about epigenetic alterations associated with body
composition in obesity. Thus, we aimed to explore epigenetic relationships between …
composition in obesity. Thus, we aimed to explore epigenetic relationships between …
Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins
W Wang, W Yao, Q Tan, S Li, H Duan, X Tian… - Diabetology & Metabolic …, 2023 - Springer
Background Elevated fasting plasma glucose (FPG) levels can increase morbidity and
mortality even when it is below the diagnostic threshold of type 2 diabetes mellitus (T2DM) …
mortality even when it is below the diagnostic threshold of type 2 diabetes mellitus (T2DM) …
m6A‐related long noncoding RNAs predict prognosis and indicate therapeutic response in endometrial carcinoma
X Zhou, H Zhang, Y Duan, J Zhu… - Journal of Clinical …, 2023 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) has been identified as the most common,
abundant, and conserved internal transcriptional modification. Long noncoding RNAs …
abundant, and conserved internal transcriptional modification. Long noncoding RNAs …
Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma
M Martin-Almeida, J Perez-Garcia, E Herrera-Luis… - Biomedicines, 2023 - mdpi.com
Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR)
and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA …
and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA …
Novel insights into the whole-blood DNA methylome of asthma in ethnically diverse children and youth
E Herrera-Luis, C Rosa-Baez… - European …, 2023 - Eur Respiratory Soc
Background The epigenetic mechanisms of asthma remain largely understudied in African
Americans and Hispanics/Latinos, two populations disproportionately affected by asthma …
Americans and Hispanics/Latinos, two populations disproportionately affected by asthma …
Mediation by DNA methylation on the association of BMI and serum uric acid in Chinese monozygotic twins
W Wang, W Li, H Duan, C Xu, X Tian, S Li, Q Tan… - Gene, 2023 - Elsevier
Obesity is an established risk factor for hyperuricemia, but the mechanisms are only partially
understood. We examined whether BMI-related DNA methylation (DNAm) variation would …
understood. We examined whether BMI-related DNA methylation (DNAm) variation would …