An overview of DNA methylation-derived trait score methods and applications

MF Nabais, DA Gadd, E Hannon, J Mill, AF McRae… - Genome Biology, 2023 - Springer
Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …

Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells

J Perez-Garcia, M Pino-Yanes, EG Plender… - Clinical …, 2023 - Springer
Background Albuterol is the first-line asthma medication used in diverse populations.
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …

Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure

W Wang, J Yao, W Li, Y Wu, H Duan, C Xu, X Tian… - Clinical …, 2023 - Springer
Background Hypertension is a crucial risk factor for developing cardiovascular disease and
reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially …

DNA methylation modulated genetic variant effect on gene transcriptional regulation

Y Zeng, R Jain, M Lam, M Ahmed, H Guo, W Xu… - Genome Biology, 2023 - Springer
Background Expression quantitative trait locus (eQTL) analysis has emerged as an
important tool in elucidating the link between genetic variants and gene expression, thereby …

Genome‐wide DNA methylation analysis of body composition in Chinese monozygotic twins

H Tian, H Qiao, F Han, X Kong, S Zhu… - European Journal of …, 2023 - Wiley Online Library
Background Little is currently known about epigenetic alterations associated with body
composition in obesity. Thus, we aimed to explore epigenetic relationships between …

Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins

W Wang, W Yao, Q Tan, S Li, H Duan, X Tian… - Diabetology & Metabolic …, 2023 - Springer
Background Elevated fasting plasma glucose (FPG) levels can increase morbidity and
mortality even when it is below the diagnostic threshold of type 2 diabetes mellitus (T2DM) …

m6A‐related long noncoding RNAs predict prognosis and indicate therapeutic response in endometrial carcinoma

X Zhou, H Zhang, Y Duan, J Zhu… - Journal of Clinical …, 2023 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) has been identified as the most common,
abundant, and conserved internal transcriptional modification. Long noncoding RNAs …

Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma

M Martin-Almeida, J Perez-Garcia, E Herrera-Luis… - Biomedicines, 2023 - mdpi.com
Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR)
and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA …

Novel insights into the whole-blood DNA methylome of asthma in ethnically diverse children and youth

E Herrera-Luis, C Rosa-Baez… - European …, 2023 - Eur Respiratory Soc
Background The epigenetic mechanisms of asthma remain largely understudied in African
Americans and Hispanics/Latinos, two populations disproportionately affected by asthma …

Mediation by DNA methylation on the association of BMI and serum uric acid in Chinese monozygotic twins

W Wang, W Li, H Duan, C Xu, X Tian, S Li, Q Tan… - Gene, 2023 - Elsevier
Obesity is an established risk factor for hyperuricemia, but the mechanisms are only partially
understood. We examined whether BMI-related DNA methylation (DNAm) variation would …